HAT1 Antibody (H-7): sc-390562

HAT1 Antibody (H-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects HAT1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). HAT1 (H-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HAT1 plays a crucial role in the acetylation of histones, which is essential for the regulation of gene expression. Specifically, anti-HAT1 antibody (H-7) targets a protein involved in the acetylation of lysine residues on histone tails, leading to structural changes in chromatin that enhance the accessibility of transcription factors to DNA. This process is vital for transcriptional activation, as HAT1 allows for the proper expression of genes necessary for various cellular functions. Conversely, the deacetylation of histones is linked to transcriptional repression, highlighting HAT1′s importance in maintaining the balance of gene expression. Additionally, HAT1 interacts with several other proteins involved in chromatin remodeling, including GCN5 and p300, further underscoring HAT1′s significance in the complex regulatory networks that govern cellular processes.

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HAT1 Antibody (H-7) References:

1. Three proteins define a class of human histone deacetylases related to yeast Hda1p.  |  Grozinger, CM., et al. 1999. Proc Natl Acad Sci U S A. 96: 4868-73. PMID: 10220385
2. Loss of HAT1 expression confers BRAFV600E inhibitor resistance to melanoma cells by activating MAPK signaling via IGF1R.  |  Bugide, S., et al. 2020. Oncogenesis. 9: 44. PMID: 32371878
3. Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-κB/HAT1/PGAM1 signaling in liver cancer.  |  Wang, YF., et al. 2023. Acta Pharmacol Sin. 44: 211-220. PMID: 35835856
4. Bevacizumab induces ferroptosis and enhances CD8+ T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9.  |  Hou, CY., et al. 2024. Acta Pharmacol Sin. 45: 1951-1963. PMID: 38760543
5. Nucleosome structural changes due to acetylation.  |  Bauer, WR., et al. 1994. J Mol Biol. 236: 685-90. PMID: 8114086
6. A positive role for histone acetylation in transcription factor access to nucleosomal DNA.  |  Lee, DY., et al. 1993. Cell. 72: 73-84. PMID: 8422685
7. Transcriptional silencing in yeast is associated with reduced nucleosome acetylation.  |  Braunstein, M., et al. 1993. Genes Dev. 7: 592-604. PMID: 8458576
8. A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p.  |  Taunton, J., et al. 1996. Science. 272: 408-11. PMID: 8602529
9. Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase.  |  Verreault, A., et al. 1998. Curr Biol. 8: 96-108. PMID: 9427644
10. Characterization of a human RPD3 ortholog, HDAC3.  |  Emiliani, S., et al. 1998. Proc Natl Acad Sci U S A. 95: 2795-800. PMID: 9501169
11. Transcriptional activators direct histone acetyltransferase complexes to nucleosomes.  |  Utley, RT., et al. 1998. Nature. 394: 498-502. PMID: 9697775
12. Roles of histone acetyltransferases and deacetylases in gene regulation.  |  Kuo, MH. and Allis, CD. 1998. Bioessays. 20: 615-26. PMID: 9780836

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HAT1 Antibody (H-7) has 9 citations in a variety of scientific publications.

Primary antibodies like Anti-HAT1 Antibody (H-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HAT1 Antibody (H-7) Specifications

Alternate Product Name: HAT1

Product Clone Name: H-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-300

Epitope Target: HAT1

Epitope Species: human

Product Reactivity/Detection: HAT1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 9 citations in various scientific publications

Available Conjugates/Forms for HAT1 Antibody (H-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin