hamartin Antibody (E-7): sc-377387
- hamartin Antibody (E-7) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of hamartin of human origin
- recommended for detection of hamartin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for hamartin Antibody (E-7). This work is in progress.
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hamartin Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects hamartin in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Hamartin plays a crucial role in the regulation of cell growth and proliferation, particularly in the context of the tuberous sclerosis complex (TSC), where hamartin′s interaction with tuberin forms a vital cytoplasmic complex essential for maintaining cellular homeostasis. This complex acts as a tumor suppressor, and dysfunction can lead to the development of hamartomas, benign tumors that can affect multiple organs, including the brain, heart, and kidneys. The presence of hamartin in these tissues underscores hamartin′s importance in normal cellular function and potential implications in TSC-related pathologies. Anti-hamartin antibody (E-7) enables researchers to gain insights into the molecular mechanisms underlying TSC and explore therapeutic avenues for managing this genetic disorder.
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hamartin Antibody (E-7) References:
- Hamartin and tuberin expression in human tissues. | Johnson, MW., et al. 2001. Mod Pathol. 14: 202-10. PMID: 11266527
- Developmental expression of the tuberous sclerosis proteins tuberin and hamartin. | Murthy, V., et al. 2001. Acta Neuropathol. 101: 202-10. PMID: 11307618
- The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton. | Haddad, LA., et al. 2002. J Biol Chem. 277: 44180-6. PMID: 12226091
- Hamartin and tuberin modulate gene transcription via beta-catenin. | Jozwiak, J. and Wlodarski, P. 2006. J Neurooncol. 79: 229-34. PMID: 16552619
- The TSC1 gene product hamartin interacts with NADE. | Yasui, S., et al. 2007. Mol Cell Neurosci. 35: 100-8. PMID: 17355907
- Association of TSC1/hamartin, 14-3-3sigma, and p27 expression with tumor outcomes in patients with pTa/pT1 urothelial bladder carcinoma. | Mhawech-Fauceglia, P., et al. 2008. Am J Clin Pathol. 129: 918-23. PMID: 18480009
- Hamartin-Hsp70 interaction is necessary for Akt-dependent tuberin phosphorylation during heat shock. | Inoue, H., et al. 2009. Biosci Biotechnol Biochem. 73: 2488-93. PMID: 19897899
- Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. | Papadakis, M., et al. 2013. Nat Med. 19: 351-7. PMID: 23435171
- Hamartin regulates cessation of mouse nephrogenesis independently of Mtor. | Volovelsky, O., et al. 2018. Proc Natl Acad Sci U S A. 115: 5998-6003. PMID: 29784808
- Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb. | Tee, AR., et al. 2022. Curr Biol. 32: 733-734. PMID: 35134350
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
hamartin Antibody (E-7) | sc-377387 | 200 µg/ml | $322.00 |