HADHA Antibody (G-9): sc-515278

HADHA Antibody (G-9) is a mouse monoclonal IgG2b antibody that detects HADHA in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). HADHA, also known as trifunctional enzyme subunit alpha, is a crucial 763 amino acid component of the mitochondrial trifunctional protein complex, which plays a vital role in the final three steps of mitochondrial beta-oxidation of long-chain fatty acids. This complex is composed of four alpha (HADHA) and four beta (HADHB) subunits, with the alpha subunit specifically responsible for catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Proper functioning of HADHA is essential for efficient fatty acid metabolism, as deficiencies in HADHA can lead to severe metabolic disorders such as long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency and mitochondrial trifunctional protein deficiency. These conditions can result in a range of clinical symptoms, including hypoglycemia, cardiomyopathy, and liver dysfunction, highlighting HADHA′s importance in maintaining metabolic homeostasis. Anti-HADHA antibody (G-9) is an invaluable tool for researchers studying these metabolic pathways and their associated disorders, providing insights into HADHA′s function and implications in human health.

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HADHA Antibody (G-9) References:

1. Association of HADHA with human RNA silencing machinery.  |  Kakumani, PK., et al. 2015. Biochem Biophys Res Commun. 466: 481-5. PMID: 26367179
2. HADHA overexpression disrupts lipid metabolism and inhibits tumor growth in clear cell renal cell carcinoma.  |  Liu, S., et al. 2019. Exp Cell Res. 384: 111558. PMID: 31472118
3. UBE2O promotes lipid metabolic reprogramming and liver cancer progression by mediating HADHA ubiquitination.  |  Ma, M., et al. 2022. Oncogene. 41: 5199-5213. PMID: 36273042
4. HADHA alleviates hepatic steatosis and oxidative stress in NAFLD via inactivation of the MKK3/MAPK pathway.  |  Ding, J., et al. 2023. Mol Biol Rep. 50: 961-970. PMID: 36376538
5. Obesity Enables NLRP3 Activation and Induces Myocardial Fibrosis via Hyperacetylation of HADHa.  |  Deng, Y., et al. 2023. Diabetes. 72: 1597-1608. PMID: 37625146
6. Morphine induces HADHA succinylation, while HADHA desuccinylation alleviates morphine tolerance by influencing autophagy.  |  Huang, Y., et al. 2024. Naunyn Schmiedebergs Arch Pharmacol. 397: 1589-1600. PMID: 37688624
7. HADHA promotes ovarian cancer outgrowth via up-regulating CDK1.  |  Liu, Y. and Xiong, Y. 2023. Cancer Cell Int. 23: 283. PMID: 37986001
8. HADHA promotes glioma progression by accelerating MDM2-mediated p53 ubiquitination.  |  Chen, R., et al. 2024. Cancer Gene Ther. 31: 1380-1389. PMID: 39039194
9. HADHA promotes esophageal cancer progression by activating mTOR signaling and the SP1/MDM2 axis.  |  Ding, X., et al. 2024. Acta Biochim Biophys Sin (Shanghai).. PMID: 39327932
10. HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS.  |  Qin, C., et al. 2024. Adv Sci (Weinh). 11: e2405147. PMID: 39488787

The preferred HADHA antibody is HADHA Antibody (E-8): sc-374497.