GSTP1 Antibody (F-6): sc-376481

GSTP1 Antibody (F-6) is a mouse monoclonal IgG2a antibody that detects Glutathione S-transferase P1 (GSTP1) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GSTP1 plays a crucial role in the metabolic detoxification of various environmental carcinogens and lipid hydroperoxides, which is vital for cellular protection against oxidative stress. Anti-GSTP1 antibody (F-6) enables detection of GSTP1 upregulation in response to oxidative stress, highlighting GSTP1′s importance in maintaining cellular homeostasis and preventing damage from reactive oxygen species. Additionally, the GSTP1 gene is subject to CpG island hypermethylation, a modification that has been associated with human prostatic carcinogenesis. This hypermethylation can be detected in biological fluids such as urine, ejaculate, and plasma from men diagnosed with prostate cancer, suggesting that GSTP1 may serve as a valuable biomarker for prostate cancer screening. GSTP1 (F-6) antibody serves as an essential tool for researchers investigating the role of GSTP1 in cancer biology and oxidative stress responses.

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GSTP1 Antibody (F-6) References:

1. Reversal of GSTP1 CpG island hypermethylation and reactivation of pi-class glutathione S-transferase (GSTP1) expression in human prostate cancer cells by treatment with procainamide.  |  Lin, X., et al. 2001. Cancer Res. 61: 8611-6. PMID: 11751372
2. GSTM1, GSTT1, and GSTP1 genotypes and the genotoxicity of hydroquinone in human lymphocytes.  |  Silva, Mdo C., et al. 2004. Environ Mol Mutagen. 43: 258-64. PMID: 15141365
3. Identification and characterization of a Pi isoform of glutathione S-transferase (GSTP1) as a zeaxanthin-binding protein in the macula of the human eye.  |  Bhosale, P., et al. 2004. J Biol Chem. 279: 49447-54. PMID: 15355982
4. Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells.  |  Tan, XL., et al. 2010. J Nutr. 140: 1404-10. PMID: 20554899
5. GSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer.  |  Miyake, T., et al. 2012. Cancer Sci. 103: 913-20. PMID: 22320227
6. miR-513a-3p sensitizes human lung adenocarcinoma cells to chemotherapy by targeting GSTP1.  |  Zhang, X., et al. 2012. Lung Cancer. 77: 488-94. PMID: 22749944
7. Single-dose GSTP1 prevents infarction-induced heart failure.  |  Andrukhova, O., et al. 2014. J Card Fail. 20: 135-45. PMID: 24412522
8. CYP1A1 and GSTP1 gene variations in breast cancer: a systematic review and case-control study.  |  Akhtar, S., et al. 2016. Fam Cancer. 15: 201-14. PMID: 26545608
9. Analysis of the GSTP1 rs1695 polymorphism association with the development of asthma and phenotypic manifestations.  |  Mukhammadiyeva, GF., et al. 2022. J Asthma. 59: 1065-1069. PMID: 33781157
10. Association Analysis of GSTP1-rs1695 Polymorphism with the Risk of Oral Cancer: A Literature Review, an Updated Meta- Analysis, and a Structural Assessment.  |  Baghaei, A., et al. 2022. Asian Pac J Cancer Prev. 23: 3859-3868. PMID: 36444599

The preferred GSTP1 antibody is GSTP1 Antibody (3F2C2): sc-66000.