GSTP1 Antibody (3F2C2): sc-66000

GSTP1 Antibody (3F2C2) is a mouse monoclonal IgG1 kappa light chain antibody that detects GSTP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). GSTP1 (3F2C2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GSTP1 protein, also known as Glutathione S-Transferase Pi 1, plays a crucial role in detoxifying harmful compounds, including environmental carcinogens and lipid hydroperoxides, thereby protecting cells from oxidative stress. This detoxification process is vital for maintaining cellular health and preventing damage that could lead to cancer. GSTP1 protein becomes upregulated in response to oxidative stress, highlighting GSTP1′s importance in cellular defense mechanisms. GSTP1 gene undergoes CpG island hypermethylation, a modification associated with prostate cancer development. GSTP1 gene hypermethylation can be detected in biological fluids such as urine, ejaculate, and plasma from men diagnosed with prostate cancer, suggesting GSTP1′s potential as a valuable biomarker for early cancer detection and screening.

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GSTP1 Antibody (3F2C2) References:

1. The human Pi class glutathione transferase sequence at 12q13-q14 is a reverse-transcribed pseudogene.  |  Board, PG., et al. 1992. Genomics. 14: 470-3. PMID: 1427860
2. GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer.  |  Nakayama, M., et al. 2004. J Cell Biochem. 91: 540-52. PMID: 14755684
3. Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells.  |  Morceau, F., et al. 2004. Biochem Pharmacol. 67: 1227-38. PMID: 15013838
4. Oxidative stress induces GSTP1 and CYP3A4 expression in the human erythroleukemia cell line, K562.  |  Nagai, F., et al. 2004. Biol Pharm Bull. 27: 492-5. PMID: 15056853
5. A systematic approach to analysing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk.  |  Spurdle, AB., et al. 2007. Cancer Epidemiol Biomarkers Prev. 16: 769-74. PMID: 17416769
6. Clinical significance and association of GSTP1 hypermethylation with hepatocellular carcinoma: A meta-analysis.  |  Li, Y., et al. 2018. J Cancer Res Ther. 14: S486-S489. PMID: 29970711
7. GSTP1 as a novel target in radiation induced lung injury.  |  Lei, X., et al. 2021. J Transl Med. 19: 297. PMID: 34238333
8. SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy.  |  Wei, C., et al. 2024. Int J Biol Sci. 20: 585-605. PMID: 38169591
9. Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer.  |  Katagiri, A., et al. 1993. Br J Cancer. 68: 125-9. PMID: 8100442
10. Mapping of glutathione transferase (GST) genes in the rat.  |  Klinga-Levan, K., et al. 1993. Hereditas. 119: 285-96. PMID: 8144363
11. Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1.  |  Simula, TP., et al. 1993. Carcinogenesis. 14: 1371-6. PMID: 8330352
12. The human glutathione S-transferase P1-1 gene: modulation of expression by retinoic acid and insulin.  |  Xia, C., et al. 1993. Biochem J. 292 (Pt 3): 845-50. PMID: 8391258

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GSTP1 Antibody (3F2C2) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-GSTP1 Antibody (3F2C2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GSTP1 Antibody (3F2C2) Specifications

Alternate Product Name: Glutathione S-Transferase

Product Clone Name: 3F2C2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: GSTP1

Epitope Species: human

Product Reactivity/Detection: GSTP1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for GSTP1 Antibody (3F2C2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin