GSTP1 Antibody (3F2C2): sc-66000
- GSTP1 Antibody (3F2C2) is a mouse monoclonal IgG1 κ GSTP1 antibody, cited in 20 publications, provided at 200 µg/ml
- raised against purified truncated recombinant GSTP1 of human origin
- GSTP1 Antibody (3F2C2) is recommended for detection of GSTP1 of human origin by WB, IP, IF and IHC(P)
- Anti-GSTP1 Antibody (3F2C2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GSTP1 Antibody (3F2C2) for WB and IHC(P) applications. These reagents are now offered in bundles with GSTP1 Antibody (3F2C2) (see ordering information below).
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GSTP1 Antibody (3F2C2) is a mouse monoclonal IgG1 kappa light chain antibody that detects GSTP1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). GSTP1 (3F2C2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GSTP1 protein, also known as Glutathione S-Transferase Pi 1, plays a crucial role in detoxifying harmful compounds, including environmental carcinogens and lipid hydroperoxides, thereby protecting cells from oxidative stress. This detoxification process is vital for maintaining cellular health and preventing damage that could lead to cancer. GSTP1 protein becomes upregulated in response to oxidative stress, highlighting GSTP1′s importance in cellular defense mechanisms. GSTP1 gene undergoes CpG island hypermethylation, a modification associated with prostate cancer development. GSTP1 gene hypermethylation can be detected in biological fluids such as urine, ejaculate, and plasma from men diagnosed with prostate cancer, suggesting GSTP1′s potential as a valuable biomarker for early cancer detection and screening.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GSTP1 Antibody (3F2C2) References:
- The human Pi class glutathione transferase sequence at 12q13-q14 is a reverse-transcribed pseudogene. | Board, PG., et al. 1992. Genomics. 14: 470-3. PMID: 1427860
- GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer. | Nakayama, M., et al. 2004. J Cell Biochem. 91: 540-52. PMID: 14755684
- Regulation of glutathione S-transferase P1-1 gene expression by NF-kappaB in tumor necrosis factor alpha-treated K562 leukemia cells. | Morceau, F., et al. 2004. Biochem Pharmacol. 67: 1227-38. PMID: 15013838
- Oxidative stress induces GSTP1 and CYP3A4 expression in the human erythroleukemia cell line, K562. | Nagai, F., et al. 2004. Biol Pharm Bull. 27: 492-5. PMID: 15056853
- A systematic approach to analysing gene-gene interactions: polymorphisms at the microsomal epoxide hydrolase EPHX and glutathione S-transferase GSTM1, GSTT1, and GSTP1 loci and breast cancer risk. | Spurdle, AB., et al. 2007. Cancer Epidemiol Biomarkers Prev. 16: 769-74. PMID: 17416769
- Clinical significance and association of GSTP1 hypermethylation with hepatocellular carcinoma: A meta-analysis. | Li, Y., et al. 2018. J Cancer Res Ther. 14: S486-S489. PMID: 29970711
- GSTP1 as a novel target in radiation induced lung injury. | Lei, X., et al. 2021. J Transl Med. 19: 297. PMID: 34238333
- SIRT5-related lysine demalonylation of GSTP1 contributes to cardiomyocyte pyroptosis suppression in diabetic cardiomyopathy. | Wei, C., et al. 2024. Int J Biol Sci. 20: 585-605. PMID: 38169591
- Immunohistochemical detection of P-glycoprotein and GSTP1-1 in testis cancer. | Katagiri, A., et al. 1993. Br J Cancer. 68: 125-9. PMID: 8100442
- Mapping of glutathione transferase (GST) genes in the rat. | Klinga-Levan, K., et al. 1993. Hereditas. 119: 285-96. PMID: 8144363
- Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B1. | Simula, TP., et al. 1993. Carcinogenesis. 14: 1371-6. PMID: 8330352
- The human glutathione S-transferase P1-1 gene: modulation of expression by retinoic acid and insulin. | Xia, C., et al. 1993. Biochem J. 292 (Pt 3): 845-50. PMID: 8391258
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSTP1 Antibody (3F2C2) | sc-66000 | 200 µg/ml | $322.00 | |||
GSTP1 Antibody (3F2C2): m-IgG Fc BP-HRP Bundle | sc-528646 | 200 µg Ab; 10 µg BP | $361.00 | |||
GSTP1 Antibody (3F2C2): m-IgGκ BP-HRP Bundle | sc-521083 | 200 µg Ab, 40 µg BP | $361.00 | |||
GSTP1 Antibody (3F2C2): m-IgG1 BP-HRP Bundle | sc-543050 | 200 µg Ab; 20 µg BP | $361.00 | |||
GSTP1 Antibody (3F2C2) AC | sc-66000 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GSTP1 Antibody (3F2C2) HRP | sc-66000 HRP | 200 µg/ml | $322.00 | |||
GSTP1 Antibody (3F2C2) FITC | sc-66000 FITC | 200 µg/ml | $336.00 | |||
GSTP1 Antibody (3F2C2) PE | sc-66000 PE | 200 µg/ml | $349.00 | |||
GSTP1 Antibody (3F2C2) Alexa Fluor® 488 | sc-66000 AF488 | 200 µg/ml | $364.00 | |||
GSTP1 Antibody (3F2C2) Alexa Fluor® 546 | sc-66000 AF546 | 200 µg/ml | $364.00 | |||
GSTP1 Antibody (3F2C2) Alexa Fluor® 594 | sc-66000 AF594 | 200 µg/ml | $364.00 | |||
GSTP1 Antibody (3F2C2) Alexa Fluor® 647 | sc-66000 AF647 | 200 µg/ml | $364.00 | |||
GSTP1 Antibody (3F2C2) Alexa Fluor® 680 | sc-66000 AF680 | 200 µg/ml | $364.00 | |||
GSTP1 Antibody (3F2C2) Alexa Fluor® 790 | sc-66000 AF790 | 200 µg/ml | $364.00 |