GSTO1 Antibody (21): sc-130317

GSTO1 Antibody (21) is a mouse monoclonal IgG2b kappa light chain antibody that detects GSTO1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GSTO1 antibody (21) is available as a non-conjugated format. GSTO1, also known as glutathione S-transferase omega 1, p28, or GSTTLp28, is a 241 amino acid protein primarily located in the cytoplasm and features both an N-terminal and a C-terminal GST domain. GSTO1 is expressed ubiquitously, with highest levels found in the heart, liver, and skeletal muscle, and functions as a homodimer. GSTO1 plays a crucial role in cellular detoxification processes, acting as a glutathione-dependent thiol transferase and a dehydroascorbate reductase. GSTO1 catalyzes the conjugation of glutathione to a diverse range of organic compounds, forming thioethers vital for the metabolism and detoxification of xenobiotics and carcinogens. Human GSTO1 shares approximately 70% sequence homology with its rodent counterpart, indicating a conserved functional role across species. Genetic polymorphisms in GSTO1 have been linked to increased risk of developing childhood acute lymphoblastic leukemia, as well as neurodegenerative disorders such as Parkinson′s disease and Alzheimer′s disease, highlighting GSTO1′s significance in both health and disease.

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GSTO1 Antibody (21) References:

1. Identification, characterization, and crystal structure of the Omega class glutathione transferases.  |  Board, PG., et al. 2000. J Biol Chem. 275: 24798-806. PMID: 10783391
2. Immunohistochemistry of omega class glutathione S-transferase in human tissues.  |  Yin, ZL., et al. 2001. J Histochem Cytochem. 49: 983-7. PMID: 11457926
3. Characterization of the human Omega class glutathione transferase genes and associated polymorphisms.  |  Whitbread, AK., et al. 2003. Pharmacogenetics. 13: 131-44. PMID: 12618591
4. Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.  |  Li, YJ., et al. 2003. Hum Mol Genet. 12: 3259-67. PMID: 14570706
5. Glutathione transferase Omega class polymorphisms in Parkinson disease.  |  Whitbread, AK., et al. 2004. Neurology. 62: 1910-1. PMID: 15159516
6. Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease.  |  Wahner, AD., et al. 2007. Neurosci Lett. 413: 274-8. PMID: 17194543
7. Polymorphism of glutathione S-transferase Omega gene: association with risk of childhood acute lymphoblastic leukemia.  |  Pongstaporn, W., et al. 2009. J Cancer Res Clin Oncol. 135: 673-8. PMID: 18941778
8. GSTO1 regulates insulin biosynthesis in pancreatic β cells.  |  Wang, L., et al. 2020. Biochem Biophys Res Commun. 524: 936-942. PMID: 32057363
9. Glutathione S-transferase omega class 1 (GSTO1)-associated large extracellular vesicles are involved in tumor-associated macrophage-mediated cisplatin resistance in bladder cancer.  |  Pan, YC., et al. 2024. Mol Oncol. 18: 1866-1884. PMID: 38750006
10. GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma.  |  Shen, NX., et al. 2024. Oncogene. 43: 2504-2516. PMID: 38969770
11. Molecular cloning and functional expression of rat liver glutathione-dependent dehydroascorbate reductase.  |  Ishikawa, T., et al. 1998. J Biol Chem. 273: 28708-12. PMID: 9786866
12. The cloning and characterization of a new stress response protein. A mammalian member of a family of theta class glutathione s-transferase-like proteins.  |  Kodym, R., et al. 1999. J Biol Chem. 274: 5131-7. PMID: 9988762

The preferred GSTO1/2 antibody is GSTO1/2 Antibody (H-12): sc-166121.