GSTM1 Antibody (1H4F2): sc-517262

GSTM1 Antibody (1H4F2) is a mouse monoclonal IgG1 kappa light chain antibody that detects GSTM1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-GSTM1 antibody (1H4F2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GSTM1 plays a crucial role in the detoxification of harmful compounds, as part of the glutathione S-transferase (GST) family, which is essential for cellular defense against toxicants and oxidative stress. Specifically, GSTM1 is involved in conjugating glutathione to a wide range of electrophilic substrates, including carcinogens and environmental toxins, thereby facilitating their excretion and reducing cellular damage. The importance of GSTM1 extends beyond detoxification; variations in GSTM1 expression can influence individual susceptibility to diseases, including cancer, making GSTM1 a significant focus of research in pharmacogenomics and toxicology. Understanding GSTM1 function and regulation is vital for developing therapeutic strategies aimed at enhancing detoxification processes in individuals exposed to harmful substances.

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GSTM1 Antibody (1H4F2) References:

1. Mechanisms of aflatoxin B1 lung tumorigenesis.  |  Massey, TE., et al. 2000. Exp Lung Res. 26: 673-83. PMID: 11195464
2. Multiple isoforms of mitochondrial glutathione S-transferases and their differential induction under oxidative stress.  |  Raza, H., et al. 2002. Biochem J. 366: 45-55. PMID: 12020353
3. Regulation of the gene encoding glutathione S-transferase M1 (GSTM1) by the Myb oncoprotein.  |  Bartley, PA., et al. 2003. Oncogene. 22: 7570-5. PMID: 14576818
4. GSTM1 and APE1 genotypes affect arsenic-induced oxidative stress: a repeated measures study.  |  Breton, CV., et al. 2007. Environ Health. 6: 39. PMID: 18053222
5. Glutathione S-transferase GSTT1 and GSTM1 allozymes: beyond null alleles.  |  Agúndez, JA. and Ladero, JM. 2008. Pharmacogenomics. 9: 359-63. PMID: 18303971
6. Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients.  |  Fukino, K., et al. 2008. J Toxicol Sci. 33: 187-95. PMID: 18544910
7. Expressions of glutathione S-transferase alpha, mu, and pi in brains of medically intractable epileptic patients.  |  Shang, W., et al. 2008. BMC Neurosci. 9: 67. PMID: 18644106
8. Glutathione S-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury.  |  Lucena, MI., et al. 2008. Hepatology. 48: 588-96. PMID: 18666253
9. Effect of the GSTM1 genotype on the biomarkers of exposure to polycyclic aromatic hydrocarbons: Meta-analysis.  |  Li, D., et al. 2017. Int J Occup Med Environ Health. 30: 177-201. PMID: 28366950
10. Relationship between GSTM1 and GSTT1 polymorphisms and HPV infection: a systematic review.  |  Bortolli, APR., et al. 2021. Mol Biol Rep. 48: 6631-6636. PMID: 34387803
11. Worldwide Systematic Review of GSTM1 and GSTT1 Null Genotypes by Continent, Ethnicity, and Therapeutic Area.  |  Nakanishi, G., et al. 2022. OMICS. 26: 528-541. PMID: 36112350
12. Increased levels of glutathione S transferases and appearance of novel alpha class isoenzymes in kidneys of mice exposed to mercuric chloride. I. Biochemical and immunohistochemical studies.  |  McGuire, S., et al. 1997. Nephron. 77: 452-60. PMID: 9434069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GSTM1 Antibody (1H4F2) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-GSTM1 Antibody (1H4F2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GSTM1 Antibody (1H4F2) Specifications

Alternate Product Name: GSTM1

Product Clone Name: 1H4F2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 23-181

Epitope Target: GSTM1

Epitope Species: human

Product Reactivity/Detection: GSTM1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for GSTM1 Antibody (1H4F2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin