GSK3 beta Antibody (2Q274): sc-71188
- GSK3 beta Antibody (2Q274) is a mouse monoclonal IgG2a, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against recombinant GSK-3β of Xenopus laevis origin
- recommended for detection of GSK-3β of human, rat and Xenopus origin by WB and IP
- See GSK3 alpha/beta (0011-A): sc-7291 for GSK3 beta antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GSK3 beta Antibody (2Q274). This work is in progress.
GSK-3β Antibody (2Q274) is a mouse monoclonal IgG2a antibody that targets glycogen synthase kinase 3 beta (GSK-3β), detecting GSK-3β in human, rat, and Xenopus samples by western blotting (WB) and immunoprecipitation (IP). GSK-3β, also referred to as GSK3, GSK-3, and GSK-3beta, is a serine/threonine kinase with a highly conserved structure, featuring a kinase domain essential for phosphorylating various substrates. GSK-3β′s structure includes an ATP-binding pocket and a catalytic core that enables interaction with other proteins, allowing regulation of multiple signaling pathways, including those involved in glycogen synthesis and cell cycle control. The structural integrity of GSK-3β is crucial for activity, as alterations in conformation can disrupt the ability to phosphorylate key substrates, leading to impaired cellular functions. GSK-3β′s kinase domain also contains regions responsible for recognizing specific phosphorylation sites on substrates, further influencing regulatory role in cellular processes. This structural precision is particularly important in maintaining normal cell functions and has been implicated in various diseases, including neurodegenerative disorders. By studying the structural features and interactions of GSK-3β, researchers can gain valuable insights into cellular regulation and the potential impact of dysregulation on disease development.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK3 beta Antibody (2Q274) | sc-71188 | 50 µg/0.5 ml | $322.00 |