GSK-3α Antibody (B-8): sc-166116

GSK-3α Antibody (B-8) is a mouse monoclonal IgG2a light chain antibody that detects glycogen synthase kinase 3 alpha (GSK-3α) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GSK-3α plays a crucial role in various cellular processes, including glycogen metabolism and cell signaling, and is particularly important due to its involvement in the regulation of the Tau protein, which is essential for microtubule stability in neurons. The hyperphosphorylation of Tau, a process mediated by GSK-3α, is a significant factor in the development of neurofibrillary tangles associated with Alzheimer′s disease. Understanding the function of GSK-3α and its interaction with Tau is vital, as dysregulation of this kinase may lead to neurodegenerative conditions. Anti-GSK-3α antibody (B-8) provides a valuable tool for researchers investigating the molecular mechanisms underlying these diseases, enabling the exploration of GSK-3α′s role in cellular signaling and its potential as a therapeutic target.

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GSK-3α Antibody (B-8) References:

1. Regulation of Notch1/NICD and Hes1 expressions by GSK-3alpha/beta.  |  Jin, YH., et al. 2009. Mol Cells. 27: 15-9. PMID: 19214430
2. Abnormalities in brain structure and behavior in GSK-3alpha mutant mice.  |  Kaidanovich-Beilin, O., et al. 2009. Mol Brain. 2: 35. PMID: 19925672
3. Tissue-specific analysis of glycogen synthase kinase-3α (GSK-3α) in glucose metabolism: effect of strain variation.  |  Patel, S., et al. 2011. PLoS One. 6: e15845. PMID: 21253590
4. Constitutively active MEK1 rescues cardiac dysfunction caused by overexpressed GSK-3α during aging and hemodynamic pressure overload.  |  Maejima, Y., et al. 2012. Am J Physiol Heart Circ Physiol. 303: H979-88. PMID: 22904158
5. Deletion of Myeloid GSK3α Attenuates Atherosclerosis and Promotes an M2 Macrophage Phenotype.  |  McAlpine, CS., et al. 2015. Arterioscler Thromb Vasc Biol. 35: 1113-22. PMID: 25767272
6. Role of PKB/SGK-dependent phosphorylation of GSK-3α/β in vascular calcification during cholecalciferol overload in mice.  |  Tuffaha, R., et al. 2018. Biochem Biophys Res Commun. 503: 2068-2074. PMID: 30119888
7. GSK3α phosphorylates dynamin-2 to promote GLUT4 endocytosis in muscle cells.  |  Laiman, J., et al. 2023. J Cell Biol. 222: PMID: 36445308
8. Elucidation of the GSK3α Structure Informs the Design of Novel, Paralog-Selective Inhibitors.  |  Amaral, B., et al. 2023. ACS Chem Neurosci. 14: 1080-1094. PMID: 36812145
9. Oxazolo[5,4-f]quinoxaline-type selective inhibitors of glycogen synthase kinase-3α (GSK-3α): Development and impact on temozolomide treatment of glioblastoma cells.  |  Hasyeoui, M., et al. 2023. Bioorg Chem. 134: 106456. PMID: 36913879
10. Germ cell-specific gene 2 accelerates cell cycle in epithelial ovarian cancer by inhibiting GSK3α-p27 cascade.  |  Zhu, K., et al. 2024. J Mol Histol. 55: 241-251. PMID: 38613588

The preferred GSK3 alpha/beta antibody is GSK3 alpha/beta Antibody (0011-A): sc-7291.