GSK-3α Antibody (10C1): sc-81463
- GSK-3α Antibody (10C1) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against GSK-3α of human origin
- recommended for detection of GSK-3α of mouse, rat, human and canine origin by WB and IP; non cross-reactive with GSK-3β
- See GSK3 alpha/beta (0011-A): sc-7291 for GSK-3α antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GSK-3α Antibody (10C1). This work is in progress.
GSK-3α Antibody (10C1) is a mouse monoclonal IgG1 antibody that detects glycogen synthase kinase 3 alpha (GSK-3α) in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. GSK-3α is a crucial serine/threonine kinase that plays a significant role in various cellular processes, including glycogen metabolism and cell signaling pathways. One of the key aspects of GSK-3α is involvement in the regulation of Tau protein, which is essential for maintaining microtubule stability in neurons. The phosphorylation of Tau by GSK-3α is particularly important because hyperphosphorylated Tau aggregates into paired helical filaments, a hallmark of neurofibrillary tangles found in Alzheimer′s disease. This aberrant phosphorylation can disrupt normal neuronal function and contribute to neurodegeneration, highlighting GSK-3α′s importance in both healthy cellular function and disease pathology. Anti-GSK-3α antibody (10C1) is an invaluable tool for researchers investigating the molecular mechanisms underlying Alzheimer′s disease and other conditions associated with Tau dysregulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GSK-3α Antibody (10C1) References:
- Distinct expression and activity of GSK-3α and GSK-3β in prostate cancer. | Darrington, RS., et al. 2012. Int J Cancer. 131: E872-83. PMID: 22539113
- Novel reporter alleles of GSK-3α and GSK-3β. | Barrell, WB., et al. 2012. PLoS One. 7: e50422. PMID: 23185619
- GSK-3α is a central regulator of age-related pathologies in mice. | Zhou, J., et al. 2013. J Clin Invest. 123: 1821-32. PMID: 23549082
- Emerging roles of GSK-3α in pathophysiology: Emphasis on cardio-metabolic disorders. | Ahmad, F. and Woodgett, JR. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118616. PMID: 31785335
- Non-redundant activity of GSK-3α and GSK-3β in T cell-mediated tumor rejection. | Steele, L., et al. 2021. iScience. 24: 102555. PMID: 34142056
- Supramolecular assembly of GSK3α as a cellular response to amino acid starvation. | Hinze, L., et al. 2022. Mol Cell. 82: 2858-2870.e8. PMID: 35732190
- Deletion of Macrophage-Specific Glycogen Synthase Kinase (GSK)-3α Promotes Atherosclerotic Regression in Ldlr-/- Mice. | Patel, S., et al. 2022. Int J Mol Sci. 23: PMID: 36012557
- Deciphering the Clinical Significance and Kinase Functions of GSK3α in Colon Cancer by Proteomics and Phosphoproteomics. | Gao, L., et al. 2023. Mol Cell Proteomics. 22: 100545. PMID: 37031867
- GSK-3α-BNIP3 axis promotes mitophagy in human cardiomyocytes under hypoxia. | Marzook, H., et al. 2024. Free Radic Biol Med. 221: 235-244. PMID: 38815772
- Identification of AS1842856 as a novel small-molecule GSK3α/β inhibitor against Tauopathy by accelerating GSK3α/β exocytosis. | He, DL., et al. 2025. Aging Cell. 24: e14336. PMID: 39287420
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GSK-3α Antibody (10C1) | sc-81463 | 50 µg/0.5 ml | $322.00 |