group IVF sPLA2 Antibody (C-6): sc-398729
- group IVF sPLA2 Antibody (C-6) is a mouse monoclonal IgG1 κ group IVF sPLA2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 794-821 near the C-terminus of group IVF sPLA2 of mouse origin
- group IVF sPLA2 Antibody (C-6) is recommended for detection of group IVF sPLA2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-group IVF sPLA2 Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for group IVF sPLA2 Antibody (C-6) for WB applications. These reagents are now offered in bundles with group IVF sPLA2 Antibody (C-6) (see ordering information below).
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Group IVF sPLA2 Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects group IVF sPLA2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-group IVF sPLA2 antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Group IVF sPLA2, also known as PLA2G4FZ or PLA2G4F, is a calcium-dependent phospholipase consisting of 849 amino acids, featuring one PLA2c domain and a C2 domain, and exists in three alternatively spliced isoforms. This enzyme plays a crucial role in lipid metabolism by hydrolyzing the sn-2-acyl ester bond in glycerophospholipids, which leads to the release of fatty acids, including arachidonic acid. Arachidonic acid is a key precursor for the synthesis of various eicosanoids, which are important signaling molecules involved in inflammatory responses. The preferential activity of group IVF sPLA2 for phosphatidylethanolamine over phosphatidylcholine highlights its specific functional role in cellular signaling and membrane dynamics, making group IVF sPLA2 a significant target for research in inflammation and related diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
group IVF sPLA2 Antibody (C-6) References:
- Cloning and characterization of novel mouse and human secretory phospholipase A(2)s. | Ishizaki, J., et al. 1999. J Biol Chem. 274: 24973-9. PMID: 10455175
- Regulation of the specific release of arachidonic acid by cytosolic phospholipase A2. | Leslie, CC. 2004. Prostaglandins Leukot Essent Fatty Acids. 70: 373-6. PMID: 15041029
- Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. | Ohto, T., et al. 2005. J Biol Chem. 280: 24576-83. PMID: 15866882
- Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. | Ghosh, M., et al. 2007. J Biol Chem. 282: 11676-86. PMID: 17293613
- HIV and SIV envelope glycoproteins induce phospholipase A2 activation in human and macaque lymphocytes. | Mavoungou, E., et al. 1997. J Acquir Immune Defic Syndr Hum Retrovirol. 16: 1-9. PMID: 9377118
- Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death. | Schröder, HC., et al. 1998. Neurotoxicology. 19: 683-8. PMID: 9745929
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
group IVF sPLA2 Antibody (C-6) | sc-398729 | 200 µg/ml | $322.00 | |||
group IVF sPLA2 Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-530906 | 200 µg Ab; 10 µg BP | $361.00 | |||
group IVF sPLA2 Antibody (C-6): m-IgGκ BP-HRP Bundle | sc-524460 | 200 µg Ab, 40 µg BP | $361.00 | |||
group IVF sPLA2 Antibody (C-6): m-IgG1 BP-HRP Bundle | sc-544312 | 200 µg Ab; 20 µg BP | $361.00 | |||
group IVF sPLA2 Antibody (C-6) AC | sc-398729 AC | 500 µg/ml, 25% agarose | $424.00 | |||
group IVF sPLA2 Antibody (C-6) HRP | sc-398729 HRP | 200 µg/ml | $322.00 | |||
group IVF sPLA2 Antibody (C-6) FITC | sc-398729 FITC | 200 µg/ml | $336.00 | |||
group IVF sPLA2 Antibody (C-6) PE | sc-398729 PE | 200 µg/ml | $349.00 | |||
group IVF sPLA2 Antibody (C-6) Alexa Fluor® 488 | sc-398729 AF488 | 200 µg/ml | $364.00 | |||
group IVF sPLA2 Antibody (C-6) Alexa Fluor® 546 | sc-398729 AF546 | 200 µg/ml | $364.00 | |||
group IVF sPLA2 Antibody (C-6) Alexa Fluor® 594 | sc-398729 AF594 | 200 µg/ml | $364.00 | |||
group IVF sPLA2 Antibody (C-6) Alexa Fluor® 647 | sc-398729 AF647 | 200 µg/ml | $364.00 | |||
group IVF sPLA2 Antibody (C-6) Alexa Fluor® 680 | sc-398729 AF680 | 200 µg/ml | $364.00 | |||
group IVF sPLA2 Antibody (C-6) Alexa Fluor® 790 | sc-398729 AF790 | 200 µg/ml | $364.00 | |||
group IVF sPLA2 (C-6) Neutralizing Peptide | sc-398729 P | 100 µg/0.5 ml | $69.00 |