GROα Antibody (5G11): sc-130316
- GROα Antibody (5G11) is a mouse monoclonal IgG1, cited in 2 publications, provided at 200 µg/ml
- raised against recombinant GROα of human origin
- recommended for detection of GROα of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GROα Antibody (5G11). This work is in progress.
GROα Antibody (5G11) is a mouse monoclonal IgG1 antibody that detects GROα in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). GROα, also known as growth-related oncogene alpha, is a member of the C-X-C chemokine subfamily, which plays a crucial role in regulating cell motility and growth. GROα is primarily secreted by activated macrophages and fibroblasts and acts as a potent chemoattractant for neutrophils, thereby facilitating their migration to sites of inflammation. GROα′s importance extends beyond immune response; GROα is also implicated in angiogenesis, the formation of new blood vessels, which is vital for tumor growth and metastasis. Notably, GROα′s interaction with specific receptors on target cells can trigger signaling pathways that promote cell proliferation and survival, making GROα a significant factor in both normal physiological processes and pathological conditions, such as cancer. Anti-GROα antibody (5G11) is an essential tool for researchers studying the mechanisms of inflammation and tumor progression, providing insights into potential therapeutic targets.
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GROα Antibody (5G11) References:
- Growth-related oncogene alpha induction of apoptosis in osteoarthritis chondrocytes. | Borzi, RM., et al. 2002. Arthritis Rheum. 46: 3201-11. PMID: 12483724
- Expression and production of the CXC chemokine growth-related oncogene-alpha by human eosinophils. | Persson-Dajotoy, T., et al. 2003. J Immunol. 170: 5309-16. PMID: 12734381
- Primary role of growth-related oncogene-alpha and granulocyte chemotactic protein-2 as neutrophil chemoattractants in chronic rhinosinusitis. | Rudack, C., et al. 2006. Clin Exp Allergy. 36: 748-59. PMID: 16776676
- Growth related oncogene-alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions. | Bechara, C., et al. 2007. Med Sci Monit. 13: RA87-90. PMID: 17534244
- Growth-related oncogene-alpha induces endothelial dysfunction through oxidative stress and downregulation of eNOS in porcine coronary arteries. | Bechara, C., et al. 2007. Am J Physiol Heart Circ Physiol. 293: H3088-95. PMID: 17873023
- Serum chemokine growth-related oncogene alpha profile during abdominal aortic aneurysm repair: preliminary report. | Jedynak, M., et al. 2009. Pol Arch Med Wewn. 119: 205-10. PMID: 19413178
- Prostaglandin I(2) analogues enhance growth-related oncogene-alpha expression in human monocyte-derived dendritic cells. | Kuo, CH., et al. 2010. Inflammation. 33: 334-43. PMID: 20195728
- Effects of vitamin D3 on the expression of growth-related oncogene-α in THP-1 cells and human primary monocytes. | Kuo, YT., et al. 2012. J Food Sci. 77: H47-52. PMID: 22251138
- Hydroxytyrosol prevents increase of osteoarthritis markers in human chondrocytes treated with hydrogen peroxide or growth-related oncogene α. | Facchini, A., et al. 2014. PLoS One. 9: e109724. PMID: 25279550
- A randomized controlled trial comparing tacrolimus versus hydrocortisone for the treatment of atopic dermatitis in children: new perspectives on interferon gamma-induced protein and growth-related oncogene-α. | Binsaleh, AY., et al. 2024. Front Med (Lausanne). 11: 1399305. PMID: 39114823
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GROα Antibody (5G11) | sc-130316 | 200 µg/ml | $316.00 |