GRF-1 Antibody (D-11): sc-390998
- GRF-1 Antibody (D-11) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 881-1080 mapping within an internal region of GRF-1 of human origin
- recommended for detection of GRF-1 isoforms 1 and 2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for GRF-1 Antibody (D-11) for WB applications. This reagent is now offered in a bundle with GRF-1 Antibody (D-11) (see ordering information below).
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SEE ALSO...
GRF-1 Antibody (D-11) is a mouse monoclonal IgG2a antibody that detects GRF-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRF-1, also known as glucocorticoid receptor DNA-binding factor 1 or p190RhoGAP, is a crucial transcriptional regulator that binds to the promoter region of the glucocorticoid receptor gene, thereby repressing its expression. This repression down-regulates Rho signaling, which is essential for mediating actin cytoskeletal rearrangements and regulating cell cycle events. GRF-1′s function is further underscored by involvement in cytokinesis, where GRF-1 modulates Rho activity through GTPase-activating protein domain, a process intricately controlled by ubiquitination of GTP binding region and subsequent degradation. Additionally, GRF-1 plays a pivotal role in oligodendrocyte differentiation, a process notably disrupted in malignant glioma tumors, suggesting GRF-1 may act as a tumor suppressor. GRF-1 expression is regulated by glucocorticoids, and GRF-1 exists in two isoforms due to alternative splicing, highlighting the complexity and importance in various cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRF-1 Antibody (D-11) | sc-390998 | 200 µg/ml | $322.00 | |||
GRF-1 Antibody (D-11): m-IgG Fc BP-HRP Bundle | sc-540882 | 200 µg Ab; 10 µg BP | $361.00 |