gremlin-1 Antibody (4C2): sc-293426
- gremlin-1 Antibody (4C2) is a mouse monoclonal IgG2a κ provided at 100 µg/ml
- raised against amino acids 75-184 representing partial length gremlin-1 of human origin
- recommended for detection of gremlin-1 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for gremlin-1 Antibody (4C2). This work is in progress.
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gremlin-1 Antibody (4C2) is a mouse monoclonal IgG2a antibody that detects gremlin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Gremlin-1 plays a crucial role in embryonic development as an antagonist of bone morphogenetic protein (BMP) signaling, which is vital for proper limb outgrowth and patterning. Specifically, gremlin-1 is involved in the fibroblast growth factor 4 (FGF4) and sonic hedgehog (SHH) feedback loop, ensuring that signaling pathways necessary for limb formation are correctly regulated. Gremlin-1 is secreted and acts in the proximal airway epithelium during embryonic development, highlighting its importance in both respiratory and limb development. Furthermore, gremlin-1′s ability to bind and inhibit BMP-2 and BMP-4 underscores its role in modulating cellular signaling pathways essential for tissue differentiation and organogenesis. Anti-gremlin-1 antibody (4C2) is an invaluable tool for researchers studying these critical developmental processes and the underlying mechanisms of BMP signaling.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
gremlin-1 Antibody (4C2) References:
- Excessive mechanical loading promotes osteoarthritis through the gremlin-1-NF-κB pathway. | Chang, SH., et al. 2019. Nat Commun. 10: 1442. PMID: 30926814
- Cancer-associated fibroblast-derived Gremlin 1 promotes breast cancer progression. | Ren, J., et al. 2019. Breast Cancer Res. 21: 109. PMID: 31533776
- Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues. | Kapoor, VN., et al. 2021. Nat Immunol. 22: 571-585. PMID: 33903764
- Gremlin-1 and BMP-4 Overexpressed in Osteoarthritis Drive an Osteochondral-Remodeling Program in Osteoblasts and Hypertrophic Chondrocytes. | Pérez-Lozano, ML., et al. 2022. Int J Mol Sci. 23: PMID: 35216203
- Gremlin1 is a therapeutically targetable FGFR1 ligand that regulates lineage plasticity and castration resistance in prostate cancer. | Cheng, C., et al. 2022. Nat Cancer. 3: 565-580. PMID: 35624341
- Gremlin-1 Promotes Colorectal Cancer Cell Metastasis by Activating ATF6 and Inhibiting ATF4 Pathways. | Li, R., et al. 2022. Cells. 11: PMID: 35883579
- BMP4 and Gremlin 1 regulate hepatic cell senescence during clinical progression of NAFLD/NASH. | Baboota, RK., et al. 2022. Nat Metab. 4: 1007-1021. PMID: 35995996
- Role of gremlin-1 in the pathophysiology of the adipose tissues. | Grillo, E., et al. 2023. Cytokine Growth Factor Rev. 69: 51-60. PMID: 36155165
- Angiogenic and Fibrogenic Dual-effect of Gremlin1 on Proliferative Diabetic Retinopathy. | Wu, X., et al. 2024. Int J Biol Sci. 20: 897-915. PMID: 38250154
- Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis. | Horn, P., et al. 2024. Elife. 13: PMID: 39361025
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
gremlin-1 Antibody (4C2) | sc-293426 | 100 µg/ml | $322.00 |