GRB7 Antibody (B-9): sc-373982
- GRB7 Antibody (B-9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-70 of GRB7 of human origin
- recommended for detection of GRB7 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for GRB7 Antibody (B-9) for WB applications. This reagent is now offered in a bundle with GRB7 Antibody (B-9) (see ordering information below).
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GRB7 Antibody (B-9) is a mouse monoclonal IgG1 antibody that detects GRB7 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRB7 plays a crucial role in cellular signaling pathways by acting as an adaptor protein that links receptor tyrosine kinases to downstream signaling molecules, thereby influencing cell proliferation and survival. GRB7′s ability to interact with various signaling proteins is vital for pathway regulation, particularly in cancer, where aberrant signaling can lead to uncontrolled cell growth. GRB7 is located in the cytoplasm and can translocate to the plasma membrane upon receptor activation, which is essential for mediating signal transduction. The amplification and overexpression of GRB7 in breast cancer highlight GRB7′s significance as a potential biomarker and therapeutic target, making anti-GRB7 antibody (B-9) an invaluable tool for researchers studying cancer biology and signaling mechanisms.
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GRB7 Antibody (B-9) References:
- The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. | Han, DC., et al. 2001. Oncogene. 20: 6315-21. PMID: 11607834
- Grb7-based molecular therapeutics in cancer. | Pero, SC., et al. 2003. Expert Rev Mol Med. 5: 1-11. PMID: 14585167
- Grb7 in intracellular signaling and its role in cell regulation. | Shen, TL. and Guan, JL. 2004. Front Biosci. 9: 192-200. PMID: 14766359
- The intertwining of structure and function: proposed helix-swapping of the SH2 domain of Grb7, a regulatory protein implicated in cancer progression and inflammation. | Pias, S., et al. 2010. Crit Rev Immunol. 30: 299-304. PMID: 20370637
- GRB7 Expression and Correlation With HER2 Amplification in Invasive Breast Carcinoma. | Bivin, WW., et al. 2017. Appl Immunohistochem Mol Morphol. 25: 553-558. PMID: 26945445
- Grb7, a Critical Mediator of EGFR/ErbB Signaling, in Cancer Development and as a Potential Therapeutic Target. | Chu, PY., et al. 2019. Cells. 8: PMID: 31083325
- Upregulated GRB7 promotes proliferation and tumorigenesis of Bladder Cancer via Phospho-AKT Pathway. | Zheng, Y., et al. 2020. Int J Biol Sci. 16: 3221-3230. PMID: 33162827
- Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer. | Yu, C., et al. 2022. Oncogene. 41: 191-203. PMID: 34718347
- GRB7 plays a promoting role in the progression of gastric cancer. | Zhu, G., et al. 2023. BMC Cancer. 23: 1262. PMID: 38129809
- TCF12-regulated GRB7 facilitates the HER2+ breast cancer progression by activating Notch1 signaling pathway. | Wang, G., et al. 2024. J Transl Med. 22: 745. PMID: 39113057
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRB7 Antibody (B-9) | sc-373982 | 200 µg/ml | $322.00 | |||
GRB7 Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-540411 | 200 µg Ab; 10 µg BP | $361.00 |