GRB2 Antibody (H-9): sc-137056
- GRB2 Antibody (H-9) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-68 mapping at the N-terminus of GRB2 of human origin
- recommended for detection of GRB2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- See GRB2 (C-7): sc-8034 for GRB2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GRB2 Antibody (H-9) for WB and IHC(P) applications. These reagents are now offered in bundles with GRB2 Antibody (H-9) (see ordering information below).
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GRB2 Antibody (H-9) is a mouse monoclonal IgG1 antibody that detects GRB2 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). GRB2 plays a crucial role in cellular signaling pathways, particularly in the regulation of growth factor receptor signaling, which is essential for cell proliferation and differentiation. GRB2 is primarily located in the cytoplasm and is recruited to the plasma membrane upon activation of receptor tyrosine kinases, such as the epidermal growth factor receptor (EGFR). GRB2 localization facilitates the assembly of signaling complexes that propagate downstream signaling cascades, ultimately influencing cellular responses to external stimuli. GRB2 interacts with several key proteins, including the guanine nucleotide exchange factor SOS1, which is critical for activating Ras proteins, thereby linking receptor activation to the Ras signaling pathway. GRB2′s ability to form complexes with these proteins underscores its importance in mediating cellular responses and highlights its potential as a target for therapeutic interventions in diseases characterized by dysregulated signaling pathways.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRB2 Antibody (H-9) | sc-137056 | 200 µg/ml | $322.00 | |||
GRB2 Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-539923 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRB2 Antibody (H-9): m-IgG1 BP-HRP Bundle | sc-541790 | 200 µg Ab; 20 µg BP | $361.00 |