GRB10 Antibody (G-3): sc-74508
- GRB10 Antibody (G-3) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-130 of GRB10 of human origin
- recommended for detection of GRB10 of human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for GRB10 Antibody (G-3) for WB applications. These reagents are now offered in bundles with GRB10 Antibody (G-3) (see ordering information below).
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GRB10 Antibody (G-3) is a mouse monoclonal IgG1 antibody that detects GRB10 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GRB10 plays a crucial role in cellular signaling pathways, particularly in growth factor receptor interactions, where GRB10 acts as a negative regulator of receptor signaling. This regulation is vital for maintaining cellular homeostasis and preventing excessive cell proliferation, which can lead to oncogenic transformations. GRB10 is primarily located in the cytoplasm and can translocate to the plasma membrane upon growth factor stimulation, allowing GRB10 to interact with various receptor tyrosine kinases, including the epidermal growth factor receptor (EGFR). Understanding the dynamics of GRB10′s cellular localization and interactions with other signaling molecules is essential for elucidating GRB10′s role in cancer biology and therapeutic resistance. Anti-GRB10 antibody (G-3) is an invaluable tool for researchers investigating the intricate signaling networks that govern cell behavior and the implications of dysregulated signaling in disease states.
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GRB10 Antibody (G-3) References:
- Grb10 adapter protein as regulator of insulin-like growth factor receptor signaling. | Morrione, A. 2003. J Cell Physiol. 197: 307-11. PMID: 14566960
- Grb10 is a dual regulator of receptor tyrosine kinase signaling. | Kabir, NN. and Kazi, JU. 2014. Mol Biol Rep. 41: 1985-92. PMID: 24420853
- Grb10 is involved in BCR-ABL-positive leukemia in mice. | Illert, AL., et al. 2015. Leukemia. 29: 858-68. PMID: 25249015
- Tissue-specific regulation and function of Grb10 during growth and neuronal commitment. | Plasschaert, RN. and Bartolomei, MS. 2015. Proc Natl Acad Sci U S A. 112: 6841-7. PMID: 25368187
- GRB10 sustains AR activity by interacting with PP2A in prostate cancer cells. | Hao, J., et al. 2021. Int J Cancer. 148: 469-480. PMID: 33038264
- GRB10 regulates β-cell mass by inhibiting β-cell proliferation and stimulating β-cell dedifferentiation. | Cai, Z., et al. 2022. J Genet Genomics. 49: 208-216. PMID: 34861413
- CircRNA GRB10 is a Novel Biomarker for the Accurate Diagnosis of Lumbar Degenerative Disc Disease. | Wei, L., et al. 2023. Mol Biotechnol. 65: 816-821. PMID: 36251122
- Hypothalamic Grb10 enhances leptin signalling and promotes weight loss. | Liu, H., et al. 2023. Nat Metab. 5: 147-164. PMID: 36593271
- GRB10 is a novel factor associated with gastric cancer proliferation and prognosis. | Ren, LL., et al. 2023. Aging (Albany NY). 15: 3394-3409. PMID: 37179120
- RILP inhibits tumor progression in osteosarcoma via Grb10-mediated inhibition of the PI3K/AKT/mTOR pathway. | Wei, Z., et al. 2023. Mol Med. 29: 133. PMID: 37789274
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRB10 Antibody (G-3) | sc-74508 | 200 µg/ml | $322.00 | |||
GRB10 Antibody (G-3): m-IgG Fc BP-HRP Bundle | sc-539537 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRB10 Antibody (G-3): m-IgG1 BP-HRP Bundle | sc-541549 | 200 µg Ab; 20 µg BP | $361.00 |