granzyme M Antibody (A-10): sc-376799
- granzyme M Antibody (A-10) is a mouse monoclonal IgG1 κ granzyme M antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 71-140 mapping within an internal region of granzyme M of human origin
- granzyme M Antibody (A-10) is recommended for detection of granzyme M of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-granzyme M Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for granzyme M Antibody (A-10) for WB applications. These reagents are now offered in bundles with granzyme M Antibody (A-10) (see ordering information below).
QUICK LINKS
SEE ALSO...
Granzyme M Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects granzyme M protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-granzyme M antibody (A-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Granzyme M, also known as NK cell granular protease or HU-Met-1, is a serine protease that plays a crucial role in the immune response by localizing to the granules of natural killer (NK) cells and cytotoxic T lymphocytes. This protein is characterized by its unique Trypsin-fold serine protease structure, which allows cleavage of peptide substrates specifically after leucine, norleucine, or methionine residues. Granzyme M′s ability to induce target cell death is vital for effective cell-mediated immune responses, as granzyme M contributes to the elimination of infected or malignant cells. Additionally, granzyme M′s interactions with other granzyme family members, such as granzyme A and granzyme B, highlight granzyme M′s importance in the apoptotic signaling pathways activated by cytotoxic lymphocytes. Using granzyme M monoclonal antibody (A-10) in research can provide valuable insights into immune regulation mechanisms and granzyme M′s role in apoptosis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
granzyme M Antibody (A-10) References:
- SPI-CI and SPI-6 cooperate in the protection from effector cell-mediated cytotoxicity. | Bots, M., et al. 2005. Blood. 105: 1153-61. PMID: 15454490
- Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B. | Mahrus, S., et al. 2004. J Biol Chem. 279: 54275-82. PMID: 15494398
- Functional analysis of granzyme M and its role in immunity to infection. | Pao, LI., et al. 2005. J Immunol. 175: 3235-43. PMID: 16116214
- Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes. | Bade, B., et al. 2005. Int Immunol. 17: 1419-28. PMID: 16186162
- KHYG-1, a model for the study of enhanced natural killer cell cytotoxicity. | Suck, G., et al. 2005. Exp Hematol. 33: 1160-71. PMID: 16219538
- Serpins prevent granzyme-induced death in a species-specific manner. | Bots, M., et al. 2006. Immunol Cell Biol. 84: 79-86. PMID: 16405655
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
granzyme M Antibody (A-10) | sc-376799 | 200 µg/ml | $316.00 | |||
granzyme M Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-529936 | 200 µg Ab; 10 µg BP | $354.00 | |||
granzyme M Antibody (A-10): m-IgGκ BP-HRP Bundle | sc-523098 | 200 µg Ab, 40 µg BP | $354.00 | |||
granzyme M Antibody (A-10): m-IgG1 BP-HRP Bundle | sc-543773 | 200 µg Ab; 20 µg BP | $354.00 | |||
granzyme M Antibody (A-10) AC | sc-376799 AC | 500 µg/ml, 25% agarose | $416.00 | |||
granzyme M Antibody (A-10) HRP | sc-376799 HRP | 200 µg/ml | $316.00 | |||
granzyme M Antibody (A-10) FITC | sc-376799 FITC | 200 µg/ml | $330.00 | |||
granzyme M Antibody (A-10) PE | sc-376799 PE | 200 µg/ml | $343.00 | |||
granzyme M Antibody (A-10) Alexa Fluor® 488 | sc-376799 AF488 | 200 µg/ml | $357.00 | |||
granzyme M Antibody (A-10) Alexa Fluor® 546 | sc-376799 AF546 | 200 µg/ml | $357.00 | |||
granzyme M Antibody (A-10) Alexa Fluor® 594 | sc-376799 AF594 | 200 µg/ml | $357.00 | |||
granzyme M Antibody (A-10) Alexa Fluor® 647 | sc-376799 AF647 | 200 µg/ml | $357.00 | |||
granzyme M Antibody (A-10) Alexa Fluor® 680 | sc-376799 AF680 | 200 µg/ml | $357.00 | |||
granzyme M Antibody (A-10) Alexa Fluor® 790 | sc-376799 AF790 | 200 µg/ml | $357.00 |