GRAMD3 Antibody (G-10): sc-515266
- GRAMD3 Antibody (G-10) is a mouse monoclonal IgG2a κ GRAMD3 antibody provided at 200 µg/ml
- raised against amino acids 206-299 mapping within an internal region of GRAMD3 of human origin
- GRAMD3 Antibody (G-10) is recommended for detection of GRAMD3 of mouse, rat, human origin by WB, IP, IF and ELISA
- Anti-GRAMD3 Antibody (G-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GRAMD3 Antibody (G-10) for WB applications. These reagents are now offered in bundles with GRAMD3 Antibody (G-10) (see ordering information below).
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GRAMD3 Antibody (G-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects GRAMD3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GRAMD3 antibody (G-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GRAMD3, consisting of 432 amino acids and characterized by a single GRAM domain, plays a crucial role in cellular processes such as membrane trafficking and apoptosis regulation. GRAMD3 localization within the endoplasmic reticulum is particularly significant, as GRAMD3 is involved in the regulation of lipid metabolism and the response to cellular stress. Dysregulation of GRAMD3 has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting GRAMD3′s importance as a potential therapeutic target. GRAMD3 gene is located on human chromosome 5q23.2, a region associated with several genetic disorders, including Cockayne syndrome and familial adenomatous polyposis, underscoring GRAMD3′s relevance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GRAMD3 Antibody (G-10) References:
- Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register. | Kadmon, M., et al. 2001. Int J Colorectal Dis. 16: 63-75. PMID: 11355321
- The gene for Treacher Collins syndrome maps to the long arm of chromosome 5. | Dixon, MJ., et al. 1991. Am J Hum Genet. 49: 17-22. PMID: 1676560
- Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair. | Cleaver, JE., et al. 2007. Neuroscience. 145: 1300-8. PMID: 17055654
- A new genomic mechanism leading to cri-du-chat syndrome. | South, ST., et al. 2006. Am J Med Genet A. 140: 2714-20. PMID: 17103439
- Redefining monosomy 5 by molecular cytogenetics in 23 patients with MDS/AML. | Herry, A., et al. 2007. Eur J Haematol. 78: 457-67. PMID: 17391336
- Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP). | Aretz, S., et al. 2007. Hum Mutat. 28: 985-92. PMID: 17486639
- Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome. | Du, HY., et al. 2007. Aging Cell. 6: 689-97. PMID: 17875000
- Molecular mechanisms of skin aging: state of the art. | Makrantonaki, E. and Zouboulis, CC. 2007. Ann N Y Acad Sci. 1119: 40-50. PMID: 18056953
- A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization. | Saltman, DL., et al. 1993. Genomics. 16: 726-32. PMID: 8325647
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GRAMD3 Antibody (G-10) | sc-515266 | 200 µg/ml | $322.00 | |||
GRAMD3 Antibody (G-10): m-IgG Fc BP-HRP Bundle | sc-531325 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRAMD3 Antibody (G-10): m-IgGκ BP-HRP Bundle | sc-524988 | 200 µg Ab, 40 µg BP | $361.00 | |||
GRAMD3 Antibody (G-10): m-IgG2a BP-HRP Bundle | sc-547763 | 200 µg Ab; 10 µg BP | $361.00 | |||
GRAMD3 Antibody (G-10) AC | sc-515266 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GRAMD3 Antibody (G-10) HRP | sc-515266 HRP | 200 µg/ml | $322.00 | |||
GRAMD3 Antibody (G-10) FITC | sc-515266 FITC | 200 µg/ml | $336.00 | |||
GRAMD3 Antibody (G-10) PE | sc-515266 PE | 200 µg/ml | $349.00 | |||
GRAMD3 Antibody (G-10) Alexa Fluor® 488 | sc-515266 AF488 | 200 µg/ml | $364.00 | |||
GRAMD3 Antibody (G-10) Alexa Fluor® 546 | sc-515266 AF546 | 200 µg/ml | $364.00 | |||
GRAMD3 Antibody (G-10) Alexa Fluor® 594 | sc-515266 AF594 | 200 µg/ml | $364.00 | |||
GRAMD3 Antibody (G-10) Alexa Fluor® 647 | sc-515266 AF647 | 200 µg/ml | $364.00 | |||
GRAMD3 Antibody (G-10) Alexa Fluor® 680 | sc-515266 AF680 | 200 µg/ml | $364.00 | |||
GRAMD3 Antibody (G-10) Alexa Fluor® 790 | sc-515266 AF790 | 200 µg/ml | $364.00 |