GPT2 Antibody (G-7): sc-398383

GPT2 Antibody (G-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects GPT2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPT2 (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GPT2, also known as alanine aminotransferase 2 (ALT2), plays a crucial role in amino acid metabolism by catalyzing the reversible transamination between alanine and 2-oxoglutarate to produce pyruvate and glutamate. This enzymatic activity is vital for maintaining nitrogen balance and energy production in tissues, particularly in muscle and adipose tissue, where GPT2 is predominantly expressed. The localization of GPT2 in these tissues underscores its importance in metabolic processes, especially during periods of fasting or exercise when amino acid catabolism is heightened. Additionally, GPT2 expression in the kidney highlights its role in the regulation of amino acid levels in the bloodstream, which is essential for overall metabolic homeostasis. With its diverse applications and critical biological functions, anti-GPT2 antibody (G-7) is an invaluable tool for researchers studying metabolic pathways and related disorders.

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GPT2 Antibody (G-7) References:

1. cDNA cloning, genomic structure, chromosomal mapping, and functional expression of a novel human alanine aminotransferase.  |  Yang, RZ., et al. 2002. Genomics. 79: 445-50. PMID: 11863375
2. Glutamate-pyruvate transaminase protects against glutamate toxicity in hippocampal slices.  |  Matthews, CC., et al. 2003. Brain Res. 978: 59-64. PMID: 12834898
3. Murine alanine aminotransferase: cDNA cloning, functional expression, and differential gene regulation in mouse fatty liver.  |  Jadhao, SB., et al. 2004. Hepatology. 39: 1297-302. PMID: 15122758
4. Liver alanine aminotransferase, insulin resistance and endothelial dysfunction in normotriglyceridaemic subjects with type 2 diabetes mellitus.  |  Schindhelm, RK., et al. 2005. Eur J Clin Invest. 35: 369-74. PMID: 15948897
5. The role of hepatic type 1 plasminogen activator inhibitor (PAI-1) during murine hemorrhagic shock.  |  Lagoa, CE., et al. 2005. Hepatology. 42: 390-9. PMID: 16025510
6. An improved model of isolated hemoperfused porcine livers using pneumatically driven pulsating blood pumps.  |  Nagel, S., et al. 2005. Toxicol Pathol. 33: 434-40. PMID: 16036860
7. Human glutamate pyruvate transaminase (GPT): localization to 8q24.3, cDNA and genomic sequences, and polymorphic sites.  |  Sohocki, MM., et al. 1997. Genomics. 40: 247-52. PMID: 9119391

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GPT2 Antibody (G-7) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-GPT2 Antibody (G-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GPT2 Antibody (G-7) Specifications

Alternate Product Name: GPT2

Product Clone Name: G-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 378-417

Epitope Target: GPT2

Epitope Species: human

Product Reactivity/Detection: GPT2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for GPT2 Antibody (G-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin