GPI Antibody (H-9): sc-271459
- GPI Antibody (H-9) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 67-102 near the N-terminus of GPI of human origin
- recommended for detection of GPI of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GPI Antibody (H-9) for WB applications. These reagents are now offered in bundles with GPI Antibody (H-9) (see ordering information below).
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GPI Antibody (H-9) is a mouse monoclonal IgG1 antibody that detects glucose-6-phosphate isomerase (GPI) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPI plays a crucial role in cellular metabolism, functioning as an essential enzyme in both glycolysis and gluconeogenesis, which are vital processes for energy production and glucose homeostasis in the body. Anti-GPI antibody (H-9) helps researchers study GPI′s role in regulating blood sugar levels and providing energy to cells, especially in tissues with high metabolic demands, such as the brain and muscles. GPI also acts as a neurotrophic factor, supporting the survival and growth of spinal and sensory neurons, which underscores its significance in neurological health. Defects or mutations in the GPI gene can lead to serious health issues, including hereditary nonspherocytic hemolytic anemia, hydrops fetalis, immediate neonatal death, and neurological impairments, highlighting the importance of GPI in both metabolic and developmental contexts. GPI monoclonal antibody (H-9) serves as an invaluable tool for researchers studying these critical pathways and their implications in various diseases.
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GPI Antibody (H-9) References:
- Immunization with glucose-6-phosphate isomerase induces T cell-dependent peripheral polyarthritis in genetically unaltered mice. | Schubert, D., et al. 2004. J Immunol. 172: 4503-9. PMID: 15034067
- Autoantibodies to glucose-6-phosphate isomerase are elevated in the synovial fluid of rheumatoid arthritis patients. | Cha, HS., et al. 2004. Scand J Rheumatol. 33: 179-84. PMID: 15228189
- Diagnostic value of glucose-6-phosphate isomerase in rheumatoid arthritis. | Fan, LY., et al. 2010. Clin Chim Acta. 411: 2049-53. PMID: 20826128
- Anti-citrullinated glucose-6-phosphate isomerase peptide antibodies in patients with rheumatoid arthritis are associated with HLA-DRB1 shared epitope alleles and disease activity. | Umeda, N., et al. 2013. Clin Exp Immunol. 172: 44-53. PMID: 23480184
- A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement. | Pizzolla, A., et al. 2013. Am J Pathol. 183: 1144-1155. PMID: 23911657
- Cell age dependent decay of human erythrocytes glucose-6-phosphate isomerase. | Fazi, A., et al. 1989. Biochim Biophys Acta. 998: 286-91. PMID: 2679892
- Suppression of glucose-6-phosphate-isomerase induced arthritis by oral administration of transgenic rice seeds expressing altered peptide ligands of glucose-6-phosphate-isomerase. | Hirota, T., et al. 2017. Mod Rheumatol. 27: 457-465. PMID: 27539357
- Discovery of ebselen as an inhibitor of Cryptosporidium parvum glucose-6-phosphate isomerase (CpGPI) by high-throughput screening of existing drugs. | Eltahan, R., et al. 2018. Int J Parasitol Drugs Drug Resist. 8: 43-49. PMID: 29414105
- Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase. | Finelli, MJ., et al. 2019. Mol Neurobiol. 56: 1558-1577. PMID: 29905912
- 6-phosphogluconate dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate isomerase, and hexokinase activity ratios in some human tumor cytosols. | Miranda, M., et al. 1978. Tumori. 64: 579-86. PMID: 741521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GPI Antibody (H-9) | sc-271459 | 200 µg/ml | $316.00 | |||
GPI Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-537640 | 200 µg Ab; 10 µg BP | $354.00 | |||
GPI Antibody (H-9): m-IgGκ BP-HRP Bundle | sc-534971 | 200 µg Ab; 40 µg BP | $354.00 | |||
GPI Antibody (H-9): m-IgG1 BP-HRP Bundle | sc-545276 | 200 µg Ab; 20 µg BP | $354.00 | |||
GPI (H-9) Neutralizing Peptide | sc-271459 P | 100 µg/0.5 ml | $68.00 |