GPI Antibody (A-5): sc-398381

GPI Antibody (A-5) is a mouse monoclonal IgG1 antibody that detects glucose-6-phosphate isomerase (GPI) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GPI is a crucial enzyme that plays a significant role in both glycolysis and gluconeogenesis, processes essential for energy production and metabolic regulation in cells. GPI exists as a cytoplasmic homodimer and is also recognized as a neurotrophic factor, particularly important for the survival and function of spinal and sensory neurons. This neurotrophic activity underscores GPI′s importance in maintaining neuronal health and function, as defects or mutations can lead to severe conditions such as hereditary nonspherocytic hemolytic anemia, hydrops fetalis, immediate neonatal death, and neurological impairments. Anti-GPI antibody (A-5) provides a reliable tool for researchers investigating GPI′s multifaceted roles in cellular metabolism and neurobiology, facilitating a deeper understanding of its implications in health and disease.

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GPI Antibody (A-5) References:

1. Low prevalence of antibodies to glucose-6-phosphate isomerase in patients with rheumatoid arthritis and a spectrum of other chronic autoimmune disorders.  |  Matsumoto, I., et al. 2003. Arthritis Rheum. 48: 944-54. PMID: 12687536
2. Association of autoantibodies to glucose-6-phosphate isomerase with extraarticular complications in rheumatoid arthritis.  |  van Gaalen, FA., et al. 2004. Arthritis Rheum. 50: 395-9. PMID: 14872481
3. Diagnostic and prognostic values of anti glucose-6-phosphate isomerase antibodies in community-recruited patients with very early arthritis.  |  Jouen, F., et al. 2004. Clin Exp Immunol. 137: 606-11. PMID: 15320914
4. Therapeutic effects of antibodies to tumor necrosis factor-alpha, interleukin-6 and cytotoxic T-lymphocyte antigen 4 immunoglobulin in mice with glucose-6-phosphate isomerase induced arthritis.  |  Matsumoto, I., et al. 2008. Arthritis Res Ther. 10: R66. PMID: 18534002
5. Arthritogenic T cell epitope in glucose-6-phosphate isomerase-induced arthritis.  |  Iwanami, K., et al. 2008. Arthritis Res Ther. 10: R130. PMID: 18992137
6. Altered peptide ligands inhibit arthritis induced by glucose-6-phosphate isomerase peptide.  |  Iwanami, K., et al. 2009. Arthritis Res Ther. 11: R167. PMID: 19900268
7. Isolation of novel animal cell lines defective in glycerolipid biosynthesis reveals mutations in glucose-6-phosphate isomerase.  |  Haller, JF., et al. 2010. J Biol Chem. 285: 866-77. PMID: 19903819
8. Identification of human basic fetoprotein as glucose-6-phosphate isomerase by using N- and C-terminal sequence tags and terminal tag database.  |  Kuyama, H., et al. 2015. J Pharm Biomed Anal. 112: 116-25. PMID: 25978494
9. Whole-transcriptome Analysis of Fully Viable Energy Efficient Glycolytic-null Cancer Cells Established by Double Genetic Knockout of Lactate Dehydrogenase A/B or Glucose-6-Phosphate Isomerase.  |  Mazzio, E., et al. 2020. Cancer Genomics Proteomics. 17: 469-497. PMID: 32859627
10. Genetic Analysis of Two Novel GPI Variants Disrupting H Bonds and Localization Characteristics of 55 Gene Variants Associated with Glucose-6-phosphate Isomerase Deficiency.  |  Xi, BX., et al. 2024. Curr Med Sci. 44: 426-434. PMID: 38561594

The preferred GPI antibody is GPI Antibody (H-10): sc-365066.