GPD1L Antibody (AT14E2): sc-517404

GPD1L Antibody (AT14E2) is a mouse monoclonal IgG1 kappa light chain antibody that detects GPD1L protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-GPD1L antibody (AT14E2) is available as the non-conjugated format. GPD1L, or glycerol-3-phosphate dehydrogenase-1 like, is a crucial enzyme in the heart, playing a significant role in the metabolism of glycerol-3-phosphate, which is essential for energy production and lipid metabolism. This 351 amino acid protein is located primarily in the mitochondria, where GPD1L catalyzes the conversion of sn-glycerol 3-phosphate and NAD+ into glycerone phosphate and NADH, thereby influencing the cellular energy balance. Proper functioning of GPD1L is vital for maintaining cardiac health, as GPD1L is involved in the trafficking of voltage-gated sodium channels to the cell surface, which is critical for the cardiac action potential and overall heart rhythm. Mutations in the GPD1L gene have been linked to Brugada syndrome type 2, a serious cardiac condition that can lead to life-threatening arrhythmias, as well as sudden infant death syndrome, highlighting the importance of GPD1L in both cardiac function and developmental health.

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GPD1L Antibody (AT14E2) References:

1. Molecular biology of sodium channels and their role in cardiac arrhythmias.  |  Grant, AO. 2001. Am J Med. 110: 296-305. PMID: 11239848
2. [Long QT syndrome and Brugada syndrome: 2 aspects of the same disease?].  |  Cerrone, M., et al. 2001. Ital Heart J Suppl. 2: 253-7. PMID: 11307783
3. Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism.  |  Clancy, CE. and Rudy, Y. 2002. Circulation. 105: 1208-13. PMID: 11889015
4. Slowed conduction and ventricular tachycardia after targeted disruption of the cardiac sodium channel gene Scn5a.  |  Papadatos, GA., et al. 2002. Proc Natl Acad Sci U S A. 99: 6210-5. PMID: 11972032
5. Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) mutations in sudden infant death syndrome.  |  Van Norstrand, DW., et al. 2007. Circulation. 116: 2253-9. PMID: 17967976
6. Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias.  |  London, B., et al. 2007. Circulation. 116: 2260-8. PMID: 17967977
7. Mutation analysis of the glycerol-3 phosphate dehydrogenase-1 like (GPD1L) gene in Japanese patients with Brugada syndrome.  |  Makiyama, T., et al. 2008. Circ J. 72: 1705-6. PMID: 18762705

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GPD1L Antibody (AT14E2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GPD1L Antibody (AT14E2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GPD1L Antibody (AT14E2) Specifications

Alternate Product Name: GPD1L

Product Clone Name: AT14E2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-351

Epitope Target: GPD1L

Epitope Species: human

Product Reactivity/Detection: GPD1L

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 1% glycerol and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GPD1L Antibody (AT14E2): N/A