GNL2 Antibody (E-2): sc-514701

GNL2 Antibody (E-2) is a mouse monoclonal IgG1 antibody that detects GNL2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GNL2, also known as autoantigen NGP-1, NOG2, or nucleolar GTP-binding protein 2, plays a vital role in the nucleolar trafficking of proteins, specifically facilitating the export of the 60S preribosomal subunit from the nucleus to the cytoplasm. This process is essential for ribosome biogenesis, which is crucial for protein synthesis in all living cells. GNL2 functions as a GTPase, utilizing the energy derived from GTP hydrolysis to drive the translocation of ribosomal components, thereby ensuring efficient protein production. Notably, GNL2 shares structural and functional similarities with nucleostemin (GNL3), another important nuclear GTPase, highlighting GNL2′s significance in cellular processes. The highest expression levels of GNL2 are found in the testis, indicating GNL2′s potential role in germ cell development and function. Anti-GNL2 antibody (E-2) is an invaluable tool for researchers studying cellular biology and related fields, providing insights into the dynamics of ribosome assembly and nucleolar function.

The preferred GNL2 antibody is GNL2 Antibody (B-8): sc-514050.