GMEB-2 Antibody (364C1a): sc-81093
- GMEB-2 Antibody (364C1a) is a mouse monoclonal IgG2b GMEB-2 antibody provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of GMEB-2 of human origin
- recommended for detection of GMEB-2 of human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GMEB-2 Antibody (364C1a). This work is in progress.
GMEB-2 Antibody (364C1a) is a mouse monoclonal IgG2b antibody that detects GMEB-2 protein of human origin by western blotting (WB) and immunoprecipitation (IP). GMEB-2 (364C1a) antibody is available as a non-conjugated anti-GMEB-2 monoclonal isotype antibody. GMEB-2, also known as glucocorticoid modulatory element binding protein 2 or PIF79 (Parvovirus initiation factor p79), is a vital DNA-binding protein that plays a significant role in modulating transcription in response to steroid hormone activation. GMEB-2 is predominantly expressed in critical developmental tissues, including the testis, bone marrow, placenta, and fetal tissues, and is localized in both the nucleus and cytoplasm. GMEB-2 features a SAND domain at its N-terminus and a coiled-coil structure at its C-terminus, which are essential for function. GMEB-2 operates as a homodimer or can form heterodimers with GMEB-1, allowing the complex to specifically bind to glucocorticoid modulatory elements (GME) in the promoter regions of target genes. This binding is crucial as GMEB-2 recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling, thereby enhancing the sensitivity of cells to low concentrations of glucocorticoids. GMEB-2 serves as an auxiliary factor necessary for the replication of parvoviruses, highlighting importance in both cellular signaling and viral biology.
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GMEB-2 Antibody (364C1a) References:
- Cloning and characterization of hGMEB1, a novel glucocorticoid modulatory element binding protein. | Thériault, JR., et al. 1999. FEBS Lett. 452: 170-6. PMID: 10386584
- Two new members of the emerging KDWK family of combinatorial transcription modulators bind as a heterodimer to flexibly spaced PuCGPy half-sites. | Christensen, J., et al. 1999. Mol Cell Biol. 19: 7741-50. PMID: 10523663
- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | Nagase, T., et al. 1999. DNA Res. 6: 337-45. PMID: 10574462
- Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family. | Jimenez-Lara, AM., et al. 2000. FEBS Lett. 468: 203-10. PMID: 10692587
- Genomic organization of human GMEB-1 and rat GMEB-2: structural conservation of two multifunctional proteins. | Zeng, H., et al. 2000. Nucleic Acids Res. 28: 1819-29. PMID: 10734202
- Properties of the glucocorticoid modulatory element binding proteins GMEB-1 and -2: potential new modifiers of glucocorticoid receptor transactivation and members of the family of KDWK proteins. | Kaul, S., et al. 2000. Mol Endocrinol. 14: 1010-27. PMID: 10894151
- Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions. | Surdo, PL., et al. 2003. Mol Endocrinol. 17: 1283-95. PMID: 12702733
- Structure/activity relationships for GMEB-2: the second member of the glucocorticoid modulatory element-binding complex. | Chen, J., et al. 2004. Biochemistry. 43: 245-55. PMID: 14705952
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GMEB-2 Antibody (364C1a) | sc-81093 | 100 µg/ml | $339.00 |