glypican-3 Antibody (1G12): sc-65443
- glypican-3 Antibody (1G12) is a mouse monoclonal IgG1, cited in 30 publications, provided at 15 µg/100 µl
- raised against a fragment containing amino acids 510-580 of glypican-3 of human origin
- recommended for detection of glypican-3 of human origin by WB, IP, IF and IHC(P)
- See glypican-3 (F-3): sc-390587 for glypican-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for glypican-3 Antibody (1G12). This work is in progress.
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SEE ALSO...
Glypican-3 Antibody (1G12) is a mouse monoclonal IgG1 antibody that detects glypican-3 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-glypican-3 antibody (1G12) recognizes an integral membrane protein that plays a crucial role in regulating tissue and organ growth, primarily through interactions with growth factors like insulin-like growth factor II (IGF-II) and fibroblast growth factor 2 (FGF-2). This regulation is vital for normal development, as dysregulation of glypican-3 can lead to conditions such as Simpson-Golabi-Behmel syndrome, characterized by significant pre- and post-natal overgrowth. Glypican-3 is anchored to the cell membrane via a glycosyl-phosphatidyl-inositol (GPI) anchor and is predominantly expressed in embryonic mesodermal tissues, including the lung, liver, and kidney. Understanding glypican-3 function is essential, as downregulation through mechanisms such as promoter hypermethylation or repression of specific transcription factors can have profound implications for growth regulation and developmental processes. Glypican-3 monoclonal antibody (1G12) serves as a valuable tool for researchers investigating this protein′s role in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
glypican-3 Antibody (1G12) | sc-65443 | 15 µg/100 µl | $316.00 |