glypican-1 Antibody (9E9): sc-101826

glypican-1 Antibody (9E9) is a mouse monoclonal IgG1 antibody that detects glypican-1 in mouse, rat, and human samples through applications such as western blotting (WB) and immunofluorescence (IF). Glypican-1, a member of the glycosylphosphatidylinositol-anchored cell surface heparan sulfate proteoglycans, plays a crucial role in various biological processes, including cell adhesion, migration, and the modulation of growth factor activities. Notably, anti-glypican-1 antibody (9E9) recognizes a protein involved in the interaction with fibroblast growth factors (FGFs), such as FGF-1, FGF-2, and FGF-7, which are essential for cellular signaling and development. Glypican-1′s heparan sulfate chains facilitate specific binding to vascular endothelial growth factor 165 (VEGF165), acting as an extracellular chaperone that restores receptor binding ability after oxidative stress. This function is particularly important in the context of hematopoietic stem and progenitor cell maintenance, as glypican-1 present on marrow stromal cells may support their development. Furthermore, elevated levels of glypican-1 in human pancreatic cancer cells compared to normal pancreatic cells suggest a significant role in the tumor microenvironment and response to mitogenic stimuli, such as FGF-2. The gene encoding human glypican-1 is located on chromosome 2q37.3, highlighting genetic significance in health and disease. Glypican-1 monoclonal antibody (9E9) serves as an invaluable tool for researchers investigating the multifaceted roles of glypican-1 in various biological contexts.

The preferred glypican-1 antibody is glypican-1 Antibody (A-10): sc-365000.