Glutathione reductase Antibody (C-10): sc-133245

Glutathione reductase Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects Glutathione reductase of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Glutathione reductase (C-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Glutathione reductase, also known as Glutathione reductase mitochondrial precursor, GRase, GSR, or GR, is a crucial enzyme belonging to the class-I pyridine nucleotide-disulfide oxidoreductase family. Glutathione reductase plays a vital role in cellular defense against oxidative stress by maintaining high levels of reduced glutathione in the cytosol, which is essential for detoxifying reactive oxygen species and protecting cellular components from oxidative damage. Glutathione reductase catalyzes the reduction of oxidized glutathione to its reduced form, utilizing NADPH as a cofactor, thereby ensuring a continuous supply of reduced glutathione for various cellular processes. Glutathione reductase can localize to both mitochondria and the cytoplasm, and forms a disulfide-linked homodimer, with an active site featuring a redox-active disulfide bond that is critical for enzymatic function.

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Glutathione reductase Antibody (C-10) References:

1. Platelet surface glutathione reductase-like activity.  |  Essex, DW., et al. 2004. Blood. 104: 1383-5. PMID: 15142878
2. Insulin neuroprotection against oxidative stress in cortical neurons--involvement of uric acid and glutathione antioxidant defenses.  |  Duarte, AI., et al. 2005. Free Radic Biol Med. 39: 876-89. PMID: 16140208
3. Protective effects of long term dietary restriction on swimming exercise-induced oxidative stress in the liver, heart and kidney of rat.  |  Aydin, C., et al. 2007. Cell Biochem Funct. 25: 129-37. PMID: 16143963
4. Modulation of Brain Glutathione Reductase and Peroxiredoxin 2 by α-Tocopheryl Phosphate.  |  Uchoa, MF., et al. 2016. Cell Mol Neurobiol. 36: 1015-1022. PMID: 26749581
5. Characterisation of naturally occurring isothiocyanates as glutathione reductase inhibitors.  |  Li, X., et al. 2020. J Enzyme Inhib Med Chem. 35: 1773-1780. PMID: 32951477
6. Refined structure of glutathione reductase at 1.54 A resolution.  |  Karplus, PA. and Schulz, GE. 1987. J Mol Biol. 195: 701-29. PMID: 3656429
7. Molecular cloning of glutathione reductase from Oryza sativa, demonstrating its peroxisomal localization and upregulation by abiotic stresses.  |  Chanda Roy, P. and Chowdhary, G. 2023. Acta Biochim Pol. 70: 175-181. PMID: 36617358
8. Purification and properties of an abnormal glutathione reductase from human erythrocytes.  |  Staal, GE., et al. 1969. Biochim Biophys Acta. 185: 63-9. PMID: 5796112
9. Glutathione reductase in the red blood cells.  |  Chang, JC., et al. 1978. Ann Clin Lab Sci. 8: 23-9. PMID: 623427
10. A role for glutathione and glutathione reductase in control of corneal hydration.  |  Riley, MV. 1984. Exp Eye Res. 39: 751-8. PMID: 6519203
11. Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.  |  Stoll, VS., et al. 1997. Biochemistry. 36: 6437-47. PMID: 9174360
12. Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers.  |  Becker, K., et al. 1998. Nat Struct Biol. 5: 267-71. PMID: 9546215

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Glutathione reductase Antibody (C-10) has 49 citations in a variety of scientific publications.

Primary antibodies like Anti-Glutathione reductase Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Glutathione reductase Antibody (C-10) Specifications

Alternate Product Name: Glutathione reductase

Product Clone Name: C-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 391-510

Epitope Target: Glutathione reductase

Epitope Species: human

Product Reactivity/Detection: Glutathione reductase

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 49 citations in various scientific publications

Available Conjugates/Forms for Glutathione reductase Antibody (C-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin