Glutathione reductase Antibody (B-12): sc-133159

Glutathione reductase Antibody (B-12) is a mouse monoclonal IgG2a antibody that detects glutathione reductase in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Glutathione reductase plays a crucial role in cellular defense against oxidative stress by maintaining high levels of reduced glutathione, a vital antioxidant that protects cells from damage caused by reactive oxygen species. Glutathione reductase is primarily located in the cytosol and mitochondria, where anti-glutathione reductase antibody (B-12) can detect its presence during catalysis of oxidized glutathione reduction, ensuring a balanced redox state within the cell. The ability of glutathione reductase to form a disulfide-linked homodimer and its redox-active disulfide bond at the active site are essential for enzymatic function, highlighting its importance in cellular metabolism and signaling pathways. Glutathione reductase monoclonal antibody (B-12) enables researchers to effectively study the expression and regulation of this critical protein, furthering our understanding of its role in health and disease.

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Glutathione reductase Antibody (B-12) References:

1. Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro.  |  Rousar, T., et al. 2010. Physiol Res. 59: 225-232. PMID: 19537930
2. Glutathione reductase/glutathione is responsible for cytotoxic elemental sulfur tolerance via polysulfide shuttle in fungi.  |  Sato, I., et al. 2011. J Biol Chem. 286: 20283-91. PMID: 21474441
3. Glutathione reductase-mediated synthesis of tellurium-containing nanostructures exhibiting antibacterial properties.  |  Pugin, B., et al. 2014. Appl Environ Microbiol. 80: 7061-70. PMID: 25193000
4. Differential molecular response of monodehydroascorbate reductase and glutathione reductase by nitration and S-nitrosylation.  |  Begara-Morales, JC., et al. 2015. J Exp Bot. 66: 5983-96. PMID: 26116026
5. Plasma glutathione reductase activity and prognosis of septic shock.  |  Kim, JS., et al. 2016. J Surg Res. 200: 298-307. PMID: 26316444
6. Dimethyl Fumarate Induces Glutathione Recycling by Upregulation of Glutathione Reductase.  |  Hoffmann, C., et al. 2017. Oxid Med Cell Longev. 2017: 6093903. PMID: 28116039
7. A new thioredoxin reductase with additional glutathione reductase activity in Haemonchus contortus.  |  Plancarte, A., et al. 2017. Exp Parasitol. 177: 82-92. PMID: 28456691
8. Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis.  |  Zhu, Z., et al. 2018. J Neurochem. 144: 93-104. PMID: 29105080
9. Glutathione reductase-mediated thiol oxidative stress suppresses metastasis of murine melanoma cells.  |  Li, X., et al. 2018. Free Radic Biol Med. 129: 256-267. PMID: 30086340
10. A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans.  |  Coppo, L., et al. 2022. Sci Adv. 8: eabm1148. PMID: 34985944

The preferred Glutathione reductase antibody is Glutathione reductase Antibody (C-10): sc-133245.