GluR-1 Antibody (G-12): sc-55509

GluR-1 Antibody (G-12) is a mouse monoclonal IgG1 kappa light chain antibody designed to target GluR-1, also known as GRIA1 or GluA1, which is a critical subunit of AMPA-type ionotropic glutamate receptors. Anti-GluR-1 antibody (G-12) is raised against a peptide near the N-terminus of human GluR-1, ensuring precise recognition of an epitope within amino acids 33-51. GluR-1 is predominantly located at the postsynaptic density of neurons, where GluR-1 plays a vital role in mediating fast excitatory neurotransmission in the central nervous system. Structurally, GluR-1 comprises ligand-binding domains and transmembrane regions that form cation-specific ion channels, essential for synaptic plasticity, learning, memory formation, and overall neural communication. GluR-1 (G-12) monoclonal antibody demonstrates broad species reactivity, effectively detecting GluR-1 from mouse, rat, human, equine, canine, bovine, and avian origins through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-GluR-1 antibody (G-12) is available in both non-conjugated form and multiple conjugated variants, including agarose, phycoerythrin (PE), fluorescein isothiocyanate (FITC), and several Alexa Fluor® conjugates, providing versatility for diverse experimental needs. GluR-1 (G-12) antibody enables researchers to achieve accurate detection and comprehensive analysis of GluR-1, thereby advancing studies in synaptic function, neural plasticity, and neurological disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GluR-1 Antibody (G-12) has 39 citations in a variety of scientific publications.

Primary antibodies like Anti-GluR-1 Antibody (G-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GluR-1 Antibody (G-12) Specifications

Alternate Product Name: Glutamate receptor AMPA type 1

Product Clone Name: G-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 33-51

Epitope Target: GluR-1

Epitope Species: human

Product Reactivity/Detection: GluR-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 39 citations in various scientific publications

Available Conjugates/Forms for GluR-1 Antibody (G-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, P: Blocking Peptide, PE: Phycoerythrin

The preferred GluR-1 antibody is GluR-1 Antibody (E-6): sc-13152.