GLUD2 Antibody (3C2): sc-293459
- GLUD2 Antibody (3C2) is a mouse monoclonal IgG2b κ, cited in 2 publications, provided at 100 µg/ml
- raised against amino acids 1-264 representing full length GLUD2 of human origin
- recommended for detection of GLUD2 of human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GLUD2 Antibody (3C2). This work is in progress.
QUICK LINKS
GLUD2 Antibody (3C2) is a mouse monoclonal IgG2b antibody that detects GLUD2 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GLUD2, also known as GDH2 or GLUDP1, is a mitochondrial matrix enzyme that plays a crucial role in recycling glutamate during neurotransmission, which is essential for maintaining synaptic function and overall brain health. GLUD2 is primarily expressed in the testis and retina, with lower expression levels in the brain, highlighting its importance in reproductive and visual processes. GLUD2 helps regulate the availability of glutamate, an excitatory neurotransmitter critical for cognitive functions such as learning and memory. Dysregulation of glutamate levels can lead to various neurological disorders, making GLUD2 a significant target for research in neurobiology and potential therapeutic interventions. Anti-GLUD2 antibody (3C2) provides a reliable tool for studying this important protein and its implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GLUD2 Antibody (3C2) References:
- The N-terminal domain of GluD2 (GluRdelta2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo. | Kakegawa, W., et al. 2009. J Neurosci. 29: 5738-48. PMID: 19420242
- Flap loop of GluD2 binds to Cbln1 and induces presynaptic differentiation. | Kuroyanagi, T. and Hirano, T. 2010. Biochem Biophys Res Commun. 398: 537-41. PMID: 20599760
- The human GLUD2 glutamate dehydrogenase and its regulation in health and disease. | Plaitakis, A., et al. 2011. Neurochem Int. 59: 495-509. PMID: 21420458
- The discovery of human of GLUD2 glutamate dehydrogenase and its implications for cell function in health and disease. | Shashidharan, P. and Plaitakis, A. 2014. Neurochem Res. 39: 460-70. PMID: 24352816
- mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor. | Dadak, S., et al. 2017. Neuropharmacology. 115: 92-99. PMID: 27276689
- Mitochondrial enzyme GLUD2 plays a critical role in glioblastoma progression. | Franceschi, S., et al. 2018. EBioMedicine. 37: 56-67. PMID: 30314897
- The architecture of GluD2 ionotropic delta glutamate receptor elucidated by cryo-EM. | Burada, AP., et al. 2020. J Struct Biol. 211: 107546. PMID: 32512155
- Functional validation of a human GLUD2 variant in a murine model of Parkinson's disease. | Zhang, W., et al. 2020. Cell Death Dis. 11: 897. PMID: 33093440
- Absence of GluD2 Antibodies in Patients With Opsoclonus-Myoclonus Syndrome. | Petit-Pedrol, M., et al. 2021. Neurology. 96: e1082-e1087. PMID: 33443132
- Evolution of Glutamate Metabolism via GLUD2 Enhances Lactate-Dependent Synaptic Plasticity and Complex Cognition. | Plaitakis, A., et al. 2024. Int J Mol Sci. 25: PMID: 38791334
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GLUD2 Antibody (3C2) | sc-293459 | 100 µg/ml | $322.00 |