Glucosidase IIβ Antibody (D-1): sc-46685

Glucosidase IIβ Antibody (D-1) is a mouse monoclonal IgG2a antibody that detects Glucosidase IIβ in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Glucosidase IIβ plays a crucial role in the proper folding and maturation of glycoproteins by trimming glucose residues from N-linked core glycans in the endoplasmic reticulum, a process essential for ensuring that proteins achieve their correct three-dimensional structures before being transported to their final destinations. Glucosidase IIβ is part of a heterodimeric complex with Glucosidase IIα, where Glucosidase IIβ contributes to enzymatic stability and localization. Notably, Glucosidase IIβ contains a C-terminal HDEL sequence that serves as an endoplasmic reticulum retention signal, ensuring proper enzyme retention within the ER for effective function. Additionally, phosphorylated Glucosidase IIβ is found at the plasma membrane and shows significant upregulation in fibroblasts stimulated by fibroblast growth factor, highlighting potential roles in cellular signaling pathways and cancer biology. Anti-Glucosidase IIβ antibody (D-1) serves as an invaluable tool for researchers studying glycoprotein processing and glycosylation implications in various diseases.

The preferred Glucosidase IIβ antibody is Glucosidase IIβ Antibody (H-4): sc-374457.