GLP-2R Antibody (1F2): sc-293310

GLP-2R Antibody (1F2) is a mouse monoclonal IgG2b kappa light chain antibody that detects GLP-2R protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GLP-2R antibody (1F2) is available as a non-conjugated format. The glucagon-like peptide 2 receptor (GLP-2R) plays a crucial role in the gastrointestinal system, where GLP-2R is primarily located on the surface of intestinal epithelial cells. This strategic localization is vital as GLP-2R mediates the effects of GLP-2, a hormone that promotes intestinal growth and enhances nutrient absorption. By binding to GLP-2, GLP-2R activates intracellular signaling pathways that lead to increased mucosal growth and improved gut function, which are essential for maintaining overall digestive health. GLP-2R activity is mediated through G-proteins that activate adenylyl cyclase, resulting in the production of cyclic AMP, a key second messenger in various cellular processes. Given GLP-2R importance in gastrointestinal physiology, GLP-2R serves as a potential therapeutic target for conditions such as inflammatory bowel disease and short bowel syndrome, making anti-GLP-2R antibody (1F2) a valuable tool for researchers studying these pathways.

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GLP-2R Antibody (1F2) References:

1. The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways.  |  Koehler, JA., et al. 2005. Mol Endocrinol. 19: 459-73. PMID: 15471943
2. The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation.  |  Estall, JL., et al. 2005. J Biol Chem. 280: 22124-34. PMID: 15817468
3. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow.  |  Guan, X., et al. 2006. Gastroenterology. 130: 150-64. PMID: 16401478
4. Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines.  |  Sams, A., et al. 2006. Eur J Pharmacol. 532: 18-23. PMID: 16448646
5. Glucagon and glucagon-like peptide receptors as drug targets.  |  Estall, JL. and Drucker, DJ. 2006. Curr Pharm Des. 12: 1731-50. PMID: 16712485
6. Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2.  |  Munroe, DG., et al. 1999. Proc Natl Acad Sci U S A. 96: 1569-73. PMID: 9990065

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GLP-2R Antibody (1F2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GLP-2R Antibody (1F2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GLP-2R Antibody (1F2) Specifications

Alternate Product Name: GLP-2R

Product Clone Name: 1F2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 69-178

Epitope Target: GLP-2R

Epitope Species: human

Product Reactivity/Detection: GLP-2R

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GLP-2R Antibody (1F2): N/A