GLIPR1 Antibody (8D9): sc-517141

GLIPR1 Antibody (8D9) is a mouse monoclonal IgG2a kappa light chain antibody that detects GLIPR1 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GLIPR1 antibody (8D9) is available as a non-conjugated monoclonal isotype antibody. GLIPR1 protein, also known as GLI pathogenesis-related 1, RTVP1, or CRISP7, is a 266 amino acid single-pass membrane protein that belongs to the cysteine-rich secretory protein (CRISP) family. GLIPR1 plays a crucial role in various cellular processes, including tumor suppression, as GLIPR1 functions as a target gene of p53, a well-known tumor suppressor. GLIPR1 is predominantly expressed in tissues such as the heart, lung, kidney, placenta, liver, and skeletal muscle, as well as in cell lines derived from nervous system tumors, highlighting GLIPR1′s potential significance in both normal physiology and cancer biology. GLIPR1 expression is notably induced by p53 overexpression, gamma irradiation, and doxorubicin treatment, suggesting GLIPR1′s involvement in cellular stress responses and tumorigenesis. GLIPR1 gene is located on human chromosome 12q21.2, and while several alternatively spliced isoforms exist, not all have been fully characterized, indicating a complex regulatory mechanism that may influence GLIPR1′s function in different cellular contexts.

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GLIPR1 Antibody (8D9) References:

1. mRTVP-1, a novel p53 target gene with proapoptotic activities.  |  Ren, C., et al. 2002. Mol Cell Biol. 22: 3345-57. PMID: 11971968
2. Related to testes-specific, vespid, and pathogenesis protein-1 (RTVP-1) is overexpressed in gliomas and regulates the growth, survival, and invasion of glioma cells.  |  Rosenzweig, T., et al. 2006. Cancer Res. 66: 4139-48. PMID: 16618735
3. Identification and characterization of RTVP1/GLIPR1-like genes, a novel p53 target gene cluster.  |  Ren, C., et al. 2006. Genomics. 88: 163-72. PMID: 16714093
4. Cloning and characterization of human RTVP-1b, a novel splice variant of RTVP-1 in glioma cells.  |  Xiang, C., et al. 2007. Biochem Biophys Res Commun. 362: 612-8. PMID: 17825796
5. The human glioma pathogenesis-related protein is structurally related to plant pathogenesis-related proteins and its gene is expressed specifically in brain tumors.  |  Murphy, EV., et al. 1995. Gene. 159: 131-5. PMID: 7607567
6. RTVP-1, a novel human gene with sequence similarity to genes of diverse species, is expressed in tumor cell lines of glial but not neuronal origin.  |  Rich, T., et al. 1996. Gene. 180: 125-30. PMID: 8973356

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GLIPR1 Antibody (8D9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GLIPR1 Antibody (8D9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GLIPR1 Antibody (8D9) Specifications

Alternate Product Name: GLIPR1

Product Clone Name: 8D9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 23-99

Epitope Target: GLIPR1

Epitope Species: human

Product Reactivity/Detection: GLIPR1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GLIPR1 Antibody (8D9): N/A