GLEPP1 Antibody (B-6): sc-365354
- GLEPP1 Antibody (B-6) is a mouse monoclonal IgG1 κ GLEPP1 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 31-310 mapping within an N-terminal extracellular domain of GLEPP1 of human origin
- GLEPP1 Antibody (B-6) is recommended for detection of GLEPP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GLEPP1 Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GLEPP1 Antibody (B-6) for WB applications. These reagents are now offered in bundles with GLEPP1 Antibody (B-6) (see ordering information below).
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GLEPP1 Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects GLEPP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GLEPP1 (B-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Glomerular epithelial protein 1 (GLEPP1), also known as protein tyrosine phosphatase U2 or receptor-type tyrosine-protein phosphatase O, is a crucial member of the protein-tyrosine phosphatase family, which plays a significant role in regulating signal transduction pathways. GLEPP1 is a Type I membrane protein characterized by eight fibronectin type-III domains and one tyrosine-protein phosphatase domain. This structural configuration enables GLEPP1 to interact with various signaling molecules, modulating cellular responses to external stimuli. GLEPP1 expression occurs primarily in kidney glomeruli, with additional presence in placenta, lung, and brain, highlighting GLEPP1′s importance in both renal function and broader physiological processes. GLEPP1′s ability to dephosphorylate specific tyrosine residues maintains cellular homeostasis and regulates pathways involved in cell growth, differentiation, and apoptosis, making GLEPP1 a key player in both normal physiology and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GLEPP1 Antibody (B-6) References:
- Sites of insertion of TnA and TnM in RP1 and its derivatives. | Grinsted, J., et al. 1979. Contrib Microbiol Immunol. 6: 16-25. PMID: 119614
- Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. | Motiwala, T., et al. 2004. Proc Natl Acad Sci U S A. 101: 13844-9. PMID: 15356345
- A novel substrate of receptor tyrosine phosphatase PTPRO is required for nerve growth factor-induced process outgrowth. | Chen, B. and Bixby, JL. 2005. J Neurosci. 25: 880-8. PMID: 15673668
- Receptor tyrosine phosphatases guide vertebrate motor axons during development. | Stepanek, L., et al. 2005. J Neurosci. 25: 3813-23. PMID: 15829633
- Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13. | Wiggins, RC., et al. 1995. Genomics. 27: 174-81. PMID: 7665166
- Cloning, expression and chromosomal localization of a novel gene for protein tyrosine phosphatase (PTP-U2) induced by various differentiation-inducing agents. | Seimiya, H., et al. 1995. Oncogene. 10: 1731-8. PMID: 7753550
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GLEPP1 Antibody (B-6) | sc-365354 | 200 µg/ml | $316.00 | |||
GLEPP1 Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-529357 | 200 µg Ab; 10 µg BP | $354.00 | |||
GLEPP1 Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-522218 | 200 µg Ab, 40 µg BP | $354.00 | |||
GLEPP1 Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-543476 | 200 µg Ab; 20 µg BP | $354.00 | |||
GLEPP1 Antibody (B-6) AC | sc-365354 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GLEPP1 Antibody (B-6) HRP | sc-365354 HRP | 200 µg/ml | $316.00 | |||
GLEPP1 Antibody (B-6) FITC | sc-365354 FITC | 200 µg/ml | $330.00 | |||
GLEPP1 Antibody (B-6) PE | sc-365354 PE | 200 µg/ml | $343.00 | |||
GLEPP1 Antibody (B-6) Alexa Fluor® 488 | sc-365354 AF488 | 200 µg/ml | $357.00 | |||
GLEPP1 Antibody (B-6) Alexa Fluor® 546 | sc-365354 AF546 | 200 µg/ml | $357.00 | |||
GLEPP1 Antibody (B-6) Alexa Fluor® 594 | sc-365354 AF594 | 200 µg/ml | $357.00 | |||
GLEPP1 Antibody (B-6) Alexa Fluor® 647 | sc-365354 AF647 | 200 µg/ml | $357.00 | |||
GLEPP1 Antibody (B-6) Alexa Fluor® 680 | sc-365354 AF680 | 200 µg/ml | $357.00 | |||
GLEPP1 Antibody (B-6) Alexa Fluor® 790 | sc-365354 AF790 | 200 µg/ml | $357.00 |