GIT1 Antibody (13): sc-135924
- GIT1 Antibody (13) is a mouse monoclonal IgG2a provided at 50 µg/0.5 ml
- raised against amino acids 664-770 of GIT1 of rat origin
- recommended for detection of GIT1 of mouse, rat and human origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GIT1 Antibody (13). This work is in progress.
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GIT1 Antibody (13) is a mouse monoclonal IgG2a antibody that detects GIT1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). GIT1, or GRK-interactor 1, plays a crucial role in the regulation of G protein-coupled receptor signaling by acting as a GTPase-activating protein for members of the ADP ribosylation factor family, which are essential for vesicular trafficking. The proper functioning of GIT1 is vital as GIT1 influences the internalization and resensitization of receptors like the β2-adrenergic receptor; overexpression of GIT1 can lead to diminished receptor signaling, which may have implications in various physiological processes and disease states. Anti-GIT1 antibody (13) enables researchers to gain insights into the dynamics of G protein signaling and its impact on cellular responses, making GIT1 (13) monoclonal antibody an invaluable tool for studies in cell biology and pharmacology.
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GIT1 Antibody (13) References:
- MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer. | Peng, H., et al. 2013. Hepatology. 57: 2299-313. PMID: 23325601
- GIT1/βPIX signaling proteins and PAK1 kinase regulate microtubule nucleation. | Černohorská, M., et al. 2016. Biochim Biophys Acta. 1863: 1282-97. PMID: 27012601
- The Arf-GAP and protein scaffold Cat1/Git1 as a multifaceted regulator of cancer progression. | Yoo, SM., et al. 2020. Small GTPases. 11: 77-85. PMID: 28981399
- Deletion of GIT1 Impacts eNOS Activity To Aggravate sFlt-1-Induced Preeclampsia Phenotype in Mice. | Zhang, S., et al. 2018. G3 (Bethesda). 8: 3377-3382. PMID: 30135105
- Periodic Mechanical Stress Stimulates GIT1-Dependent Mitogenic Signals in Rat Chondrocytes Through ERK1/2 Activity. | Ren, K., et al. 2018. Cell Physiol Biochem. 50: 1015-1028. PMID: 30355914
- Microcephaly with altered cortical layering in GIT1 deficiency revealed by quantitative neuroimaging. | Badea, A., et al. 2021. Magn Reson Imaging. 76: 26-38. PMID: 33010377
- GIT1 protects against breast cancer growth through negative regulation of Notch. | Zhang, S., et al. 2022. Nat Commun. 13: 1537. PMID: 35318302
- β-PIX cooperates with GIT1 to regulate endothelial nitric oxide synthase in sinusoidal endothelial cells. | Liu, S., et al. 2022. Am J Physiol Gastrointest Liver Physiol. 323: G511-G522. PMID: 36044673
- Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling. | Xu, T., et al. 2023. Redox Biol. 62: 102682. PMID: 36963288
- Macrophage GIT1 promotes oligodendrocyte precursor cell differentiation and remyelination after spinal cord injury. | Liu, H., et al. 2024. Glia. 72: 1674-1692. PMID: 38899731
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GIT1 Antibody (13) | sc-135924 | 50 µg/0.5 ml | $322.00 |