GIMAP4 Antibody (H-8): sc-515241

GIMAP4 Antibody (H-8) is a mouse monoclonal IgG1 antibody that detects GIMAP4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GIMAP4, also known as immunity-associated protein 4 or immunity-associated nucleotide 1 protein, is a 329 amino acid protein that plays a crucial role in regulating lymphomyeloid cell survival, particularly during T-helper cell differentiation. GIMAP4 contains five conserved motifs characteristic of GTP-binding proteins and features a C-terminal coiled-coil region likely involved in mediating protein-protein interactions. GIMAP4 exhibits intrinsic GTPase activity, which is significantly influenced by magnesium concentration for GDP binding, highlighting GIMAP4′s importance in cellular signaling pathways. GIMAP4 expression is specifically observed in resting T and B lymphocytes, with levels markedly decreasing upon activation of these cells, indicating GIMAP4′s potential role in T cell apoptosis regulation. GIMAP4′s ability to modulate lymphocyte survival makes GIMAP4 a vital component in understanding immune responses and could provide insights into therapeutic strategies for immune-related disorders.

The preferred GIMAP4 antibody is GIMAP4 Antibody (C-4): sc-515595.