ghrelin Antibody (2F4): sc-293422

ghrelin Antibody (2F4) is a mouse monoclonal IgG2a kappa light chain antibody that detects ghrelin protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-ghrelin antibody (2F4) is available as a non-conjugated format. Ghrelin, often referred to as the "hunger hormone," plays a vital role in regulating energy balance and appetite by stimulating growth hormone release from the pituitary gland. This acylated peptide is primarily produced in the stomach and influences various physiological processes, including glucose metabolism and gastrointestinal motility. Ghrelin′s interaction with growth hormone secretagogue receptor (GHS-R) is crucial for function, as this interaction not only promotes growth hormone release but also modulates appetite and energy expenditure. The gene encoding ghrelin is located on human chromosome 3p26-p25, and expression is tightly regulated, making ghrelin an important target for research in metabolic disorders and obesity. ghrelin monoclonal antibody (2F4) is an essential tool for scientists studying the intricate mechanisms of appetite regulation and growth hormone signaling pathways.

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ghrelin Antibody (2F4) References:

1. Ghrelin is a growth-hormone-releasing acylated peptide from stomach.  |  Kojima, M., et al. 1999. Nature. 402: 656-60. PMID: 10604470
2. Ghrelin acts in the central nervous system to stimulate gastric acid secretion.  |  Date, Y., et al. 2001. Biochem Biophys Res Commun. 280: 904-7. PMID: 11162609
3. Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration.  |  Toshinai, K., et al. 2001. Biochem Biophys Res Commun. 281: 1220-5. PMID: 11243865
4. Evolution of the growth hormone-releasing factor (GRF) family of peptides.  |  Campbell, RM. and Scanes, CG. 1992. Growth Regul. 2: 175-91. PMID: 1290954
5. Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.  |  Mayo, KE. 1992. Mol Endocrinol. 6: 1734-44. PMID: 1333056
6. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors.  |  Gaytan, F., et al. 2004. J Clin Endocrinol Metab. 89: 400-9. PMID: 14715878
7. A receptor in pituitary and hypothalamus that functions in growth hormone release.  |  Howard, AD., et al. 1996. Science. 273: 974-7. PMID: 8688086
8. Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.  |  McKee, KK., et al. 1997. Mol Endocrinol. 11: 415-23. PMID: 9092793
9. Growth hormone-releasing peptide (GHRP).  |  Bowers, CY. 1998. Cell Mol Life Sci. 54: 1316-29. PMID: 9893708

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ghrelin Antibody (2F4) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-ghrelin Antibody (2F4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ghrelin Antibody (2F4) Specifications

Alternate Product Name: Obestatin

Product Clone Name: 2F4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-117

Epitope Target: ghrelin

Epitope Species: human

Product Reactivity/Detection: ghrelin

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for ghrelin Antibody (2F4): N/A

The preferred ghrelin antibody is ghrelin Antibody (C1): sc-517596.