ghrelin Activators
Ghrelin activators constitute a diverse class of compounds that play a pivotal role in modulating the activity of the ghrelin peptide and its receptor. Ghrelin, predominantly produced by the stomach, serves as a multifunctional hormone involved in appetite regulation, energy homeostasis, and metabolic processes. The identified ghrelin activators can be broadly categorized into direct agonists and indirect modulators, each offering unique insights into the intricate signaling pathways associated with ghrelin function. Direct ghrelin activators, such as GHRP-6, Hexarelin, MK-0677, and Anamorelin, exert their effects by directly binding to the ghrelin receptor, initiating downstream signaling cascades. These compounds mimic the natural ligand, ghrelin, and elicit responses akin to endogenous ghrelin release. Their specific interaction with the ghrelin receptor provides valuable tools for understanding the receptor's pharmacology, unraveling the complexities of ghrelin signaling, and exploring applications related to metabolic regulation.
On the other hand, indirect ghrelin activators, including inhibitors of ghrelin acylation (Ghrelin O-acyltransferase Inhibitors 1 and 2), calcium channel blockers (Nifedipine), herbal medicines (Rikkunshito), antioxidants (N-acetylcysteine), TRPV1 receptor modulators (Capsaicin), and zinc, influence ghrelin activity through various pathways. These compounds either impact ghrelin bioavailability, alter cellular redox status, or modulate sensory processes, indirectly shaping ghrelin-mediated responses. This diversity underscores the multifaceted nature of ghrelin regulation and provides avenues for exploring novel interventions in metabolic disorders and appetite-related conditions. In summary, the comprehensive understanding of ghrelin activators, encompassing both direct agonists and indirect modulators, contributes to unraveling the intricate web of signaling pathways associated with ghrelin function. These compounds serve as valuable tools for researchers studying metabolic regulation, appetite control, and strategies targeting ghrelin in various physiological and pathological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anamorelin | 249921-19-5 | sc-480157 | 10 mg | $260.00 | ||
Anamorelin, a ghrelin receptor agonist, directly activates ghrelin signaling. This direct activation mimics the effects of endogenous ghrelin, providing a pharmacological tool to explore ghrelin-mediated pathways. Anamorelin's specificity for ghrelin receptors makes it a valuable compound for studying ghrelin-related physiological processes and their potential implications in metabolic regulation and homeostasis. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine, a calcium channel blocker, indirectly activates ghrelin by influencing intracellular calcium levels. Modulation of calcium dynamics impacts ghrelin release, potentially altering its physiological effects. This indirect activation emphasizes the intricate connections between calcium signaling and ghrelin regulation, contributing to our understanding of the complex interplay between cellular processes and ghrelin-mediated responses. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-acetylcysteine (NAC), a precursor of glutathione, indirectly activates ghrelin by modulating oxidative stress. Reduction of oxidative stress impacts ghrelin release, potentially altering its physiological effects. This indirect activation underscores the connection between cellular redox status and ghrelin regulation, contributing to our understanding of the complex interplay between oxidative stress and ghrelin-mediated responses. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, an active component of chili peppers, indirectly activates ghrelin by influencing TRPV1 receptor signaling. Activation of TRPV1 receptors impacts ghrelin release, potentially altering its physiological effects. This indirect activation highlights the intricate connections between TRPV1 receptor signaling and ghrelin regulation, contributing to our understanding of the complex interplay between sensory processes and ghrelin-mediated responses. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc, an essential trace element, indirectly activates ghrelin by modulating intracellular zinc levels. Changes in zinc dynamics impact ghrelin release, potentially altering its physiological effects. This indirect activation emphasizes the intricate connections between zinc homeostasis and ghrelin regulation, contributing to our understanding of the complex interplay between trace elements and ghrelin-mediated responses. | ||||||