GGTase-Iβ Antibody (H-3): sc-376655

GGTase-Iβ Antibody (H-3) is a mouse monoclonal IgG1 antibody that detects GGTase-Iβ in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GGTase-Iβ plays a crucial role in the post-translational modification of proteins, specifically through the geranylgeranylation process, which is essential for the proper functioning of various signaling pathways, including the TGF-β1 signaling pathway. This modification involves the addition of a 20-carbon geranylgeranyl group to the C-terminal cysteine residues of target proteins, which is vital for their membrane localization and activity. The presence of the C-terminal CAAX motif, where "A" represents an aliphatic amino acid and "X" is leucine, is a key determinant for the substrate specificity of GGTase-Iβ. By facilitating the geranylgeranylation of proteins, GGTase-Iβ ensures the activation of Rab GTPases, which are critical for intracellular vesicle trafficking and cellular communication. GGTase-Iβ (H-3) antibody is an invaluable tool for researchers studying the dynamics of protein modification and its implications in cellular signaling and disease mechanisms.

The preferred GGTase-Iβ antibody is GGTase-Iβ Antibody (D-11): sc-376854.