GGT1 Antibody (F-7): sc-374495

GGT1 Antibody (F-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects GGT1 of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GGT1 (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GGT1, also known as gamma-glutamyltransferase 1, plays a crucial role in glutathione metabolism, acting as a glutathionase that catalyzes the transfer of glutamyl moiety from glutathione to various amino acids and dipeptide acceptors. This enzymatic activity maintains cellular redox balance and facilitates detoxification of harmful compounds. GGT1 is predominantly located on the outer surface of cell membranes and is widely distributed across mammalian tissues, particularly in the liver, where activity significantly increases in certain liver diseases. GGT1 release into the bloodstream following liver damage makes this protein a potential early biomarker for hepatocellular carcinoma. While GGT5 converts leukotriene C4 to leukotriene D4, GGT5 does not act on synthetic substrates typically used in GGT assays. In human serum and tissues, GGT1 exhibits marked heterogeneity, attributed to variations in glycosylation rather than differences in gene products.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GGT1 Antibody (F-7) References:

1. Pooling-based genome-wide association study implicates gamma-glutamyltransferase 1 (GGT1) gene in pancreatic carcinogenesis.  |  Diergaarde, B., et al. 2010. Pancreatology. 10: 194-200. PMID: 20484958
2. Variation in the γ-glutamyltransferase 1 gene and risk of chronic pancreatitis.  |  Brand, H., et al. 2013. Pancreas. 42: 836-40. PMID: 23462328
3. Phenotypic characterization of Ggt1(dwg/dwg) mice,a mouse model for hereditary γ-glutamyltransferase deficiency.  |  Yamada, K., et al. 2013. Exp Anim. 62: 151-7. PMID: 23615310
4. Interactive effects of a common γ-glutamyltransferase 1 variant and low high-density lipoprotein-cholesterol on diabetic macro- and micro-angiopathy.  |  Jinnouchi, H., et al. 2015. Cardiovasc Diabetol. 14: 49. PMID: 25952030
5. A functional variant in the γ-glutamyltransferase (GGT)1 gene is associated with airflow obstruction in smokers.  |  Morita, K., et al. 2015. Clin Chem Lab Med. 53: e339-41. PMID: 26083269
6. Association of matrix metalloproteinase 3 and γ-glutamyltransferase 1 gene polymorphisms with the cardio-ankle vascular index in young Russians.  |  Sorokin, AV., et al. 2016. Cardiol Young. 26: 1238-40. PMID: 27161754
7. Gamma-Glutamyltransferase 1 Promotes Clear Cell Renal Cell Carcinoma Initiation and Progression.  |  Bansal, A., et al. 2019. Mol Cancer Res. 17: 1881-1892. PMID: 31151999
8. Highly Elevated Plasma γ-Glutamyltransferase Elevations: A Trait Caused by γ-Glutamyltransferase 1 Transmembrane Mutations.  |  De Grandi, A., et al. 2020. Hepatology. 71: 1124-1127. PMID: 31520399
9. Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosis.  |  Hayashima, K. and Katoh, H. 2022. J Biol Chem. 298: 101703. PMID: 35148992
10. GGT1 Suppresses the Development of Ferroptosis and Autophagy in Mouse Retinal Ganglion Cell Through Targeting GCLC.  |  Xu, G., et al. 2023. Eye Brain. 15: 139-151. PMID: 38020723

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GGT1 Antibody (F-7) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-GGT1 Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GGT1 Antibody (F-7) Specifications

Alternate Product Name: Glutamyltransferase

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 351-389

Epitope Target: GGT1

Epitope Species: mouse

Product Reactivity/Detection: GGT1 heavy chain

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for GGT1 Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred GGT1 antibody is GGT1 Antibody (E-5): sc-166908.