G_{γ 2/3/4/7} Antibody (C-5): sc-166419

Gγ 2/3/4/7 Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects G gamma 2/3/4/7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-G gamma 2/3/4/7 antibody (C-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. G gamma 2/3/4/7 protein plays a crucial role in the function of heterotrimeric G proteins, which are essential for transmitting signals from cell surface receptors to intracellular effectors. G gamma proteins are located on the inner membrane of cells, where they interact with a wide array of receptors that detect diverse extracellular stimuli such as hormones, neurotransmitters, and sensory signals. Proper localization of G gamma proteins is vital for ensuring that signaling pathways are activated in response to specific stimuli, thereby influencing various physiological processes, including cell growth, differentiation, and metabolism. G gamma subunits form distinct complexes with different alpha and beta subunits, which enhances the functional diversity of G protein signaling in various tissues. This complexity underscores the importance of G gamma proteins in maintaining cellular communication and response mechanisms, making G gamma 2/3/4/7 (C-5) monoclonal antibody an invaluable tool for researchers studying G protein signaling pathways.

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G_{γ 2/3/4/7} Antibody (C-5) References:

1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes.  |  Hurowitz, EH., et al. 2000. DNA Res. 7: 111-20. PMID: 10819326
2. G protein betagamma complexes in circumvallate taste cells involved in bitter transduction.  |  Rössler, P., et al. 2000. Chem Senses. 25: 413-21. PMID: 10944505
3. Different beta-subunits determine G-protein interaction with transmembrane receptors.  |  Kleuss, C., et al. 1992. Nature. 358: 424-6. PMID: 1322501
4. Activation of cytosolic phosphoinositide phospholipase C by G-protein beta gamma subunits.  |  Blank, JL., et al. 1992. J Biol Chem. 267: 23069-75. PMID: 1331076
5. Diversity among the beta subunits of heterotrimeric GTP-binding proteins: characterization of a novel beta-subunit cDNA.  |  von Weizsäcker, E., et al. 1992. Biochem Biophys Res Commun. 183: 350-6. PMID: 1543505
6. Diversity of G proteins in signal transduction.  |  Simon, MI., et al. 1991. Science. 252: 802-8. PMID: 1902986
7. G protein diversity is increased by associations with a variety of gamma subunits.  |  Gautam, N., et al. 1990. Proc Natl Acad Sci U S A. 87: 7973-7. PMID: 2122451
8. Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human.  |  Blatt, C., et al. 1988. Proc Natl Acad Sci U S A. 85: 7642-6. PMID: 2902634
9. Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors.  |  Dexter, PM., et al. 2018. eNeuro. 5: PMID: 29911170
10. Components of the Gs signaling cascade exhibit distinct changes in mobility and membrane domain localization upon β2 -adrenergic receptor activation.  |  Bondar, A., et al. 2020. Traffic. 21: 324-332. PMID: 32096320
11. Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α2a-adrenergic receptors.  |  Yim, YY., et al. 2021. Sci Signal. 14: eabc4970. PMID: 34932372
12. Structural Basis of the Interaction of the G Proteins, Gαi1, Gβ1γ2 and Gαi1β1γ2, with Membrane Microdomains and Their Relationship to Cell Localization and Activity.  |  Álvarez, R. and Escribá, PV. 2023. Biomedicines. 11: PMID: 36831093

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-G_{γ 2/3/4/7} Antibody (C-5) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-G_{γ 2/3/4/7} Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

G_{γ 2/3/4/7} Antibody (C-5) Specifications

Alternate Product Name: Gγ 2/3/4/7

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-71

Epitope Target: Gγ 2

Epitope Species: human

Product Reactivity/Detection: G_{γ 2,} G_{γ 3,} G_{γ 4} and G_{γ 7}

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for G_{γ 2/3/4/7} Antibody (C-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin