GFRα-1 Antibody (E-11): sc-271546

GFRα-1 Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects GFRα-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GFRα-1 (E-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GFRα-1 plays a crucial role in neuronal survival and differentiation, primarily functioning as a receptor for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN), which are essential for maintaining both central and peripheral neurons. GFRα-1 is located on the cell membrane, where a glycosyl-phosphoinositol linkage enables interaction with ligands and subsequent activation of tyrosine kinase Ret, leading to downstream signaling pathways that promote neuronal health. GFRα-1′s significance in neurotrophic signaling highlights potential therapeutic applications in neurodegenerative diseases, making anti-GFRα-1 antibody (E-11) an invaluable tool for studying neuronal function and survival mechanisms.

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GFRα-1 Antibody (E-11) References:

1. GFRalpha-1 mRNA in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area.  |  Sarabi, A., et al. 2001. J Comp Neurol. 441: 106-17. PMID: 11745638
2. Evidence for a ligand-specific signaling through GFRalpha-1, but not GFRalpha-2, in the absence of Ret.  |  Pezeshki, G., et al. 2001. J Neurosci Res. 66: 390-5. PMID: 11746356
3. XIB4035, a novel nonpeptidyl small molecule agonist for GFRalpha-1.  |  Tokugawa, K., et al. 2003. Neurochem Int. 42: 81-6. PMID: 12441171
4. Induction of GDNF and GFRα-1 Following AAV1-Rheb(S16H) Administration in the Hippocampus in vivo.  |  Yun, D., et al. 2020. Exp Neurobiol. 29: 164-175. PMID: 32408406
5. GFRα-1 is a reliable marker of bovine gonocytes/undifferentiated spermatogonia: A mini-review.  |  Zhang, XM. 2021. Anat Histol Embryol. 50: 13-14. PMID: 32761645
6. Aberrantly expressed GFRα-1/RET in patients with lacrimal adenoid cystic carcinoma is associated with high recurrence risk: a retrospective study of 51 LACC cases.  |  Liu, L., et al. 2021. Cancer Biol Med. 18: 199-205. PMID: 33628594
7. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.  |  Lin, LF., et al. 1993. Science. 260: 1130-2. PMID: 8493557
8. Characterization of a multicomponent receptor for GDNF.  |  Treanor, JJ., et al. 1996. Nature. 382: 80-3. PMID: 8657309
9. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF.  |  Jing, S., et al. 1996. Cell. 85: 1113-24. PMID: 8674117
10. Neurturin, a relative of glial-cell-line-derived neurotrophic factor.  |  Kotzbauer, PT., et al. 1996. Nature. 384: 467-70. PMID: 8945474
11. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.  |  Baloh, RH., et al. 1997. Neuron. 18: 793-802. PMID: 9182803
12. Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor.  |  Naveilhan, P., et al. 1998. Proc Natl Acad Sci U S A. 95: 1295-300. PMID: 9448325

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GFRα-1 Antibody (E-11) has 33 citations in a variety of scientific publications.

Primary antibodies like Anti-GFRα-1 Antibody (E-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GFRα-1 Antibody (E-11) Specifications

Alternate Product Name: GFRA1

Product Clone Name: E-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 368-437

Epitope Target: GFRα-1

Epitope Species: human

Product Reactivity/Detection: GFRα-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 33 citations in various scientific publications

Available Conjugates/Forms for GFRα-1 Antibody (E-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin