GFAP Antibody (F-7): sc-166458

GFAP Antibody (F-7) is a mouse monoclonal IgG1 kappa light chain antibody designed to detect glial fibrillary acidic protein (GFAP), an essential intermediate filament protein predominantly expressed in astroglial cells within the central nervous system. Targeting an epitope between amino acids 2-19 at the N-terminus of human GFAP, anti-GFAP antibody (F-7) is effective in recognizing GFAP from mouse, rat, and human species through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). GFAP, also known as ALXDRD, plays a critical role in maintaining the structural integrity and mechanical resilience of astrocytes, facilitating intracellular transport, and supporting cellular responses to injury and stress. The function of GFAP is vital for astrocyte-mediated processes like neurotransmitter regulation, blood-brain barrier maintenance, and response to neurological insults. Elevated GFAP expression is a hallmark of astrogliosis, a reactive process associated with various neuropathological conditions including mechanical trauma, inflammatory demyelinating diseases, prion infections, and AIDS related dementia. By providing precise localization and quantification of GFAP, GFAP monoclonal antibody (F-7) serves as an invaluable tool for researchers studying the molecular mechanisms underlying neural health, disease progression, and the role of astrocytes in maintaining central nervous system homeostasis. Available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, GFAP (F-7) antibody is indispensable for advancing our understanding of astrocyte biology and the pathophysiology of numerous neurological disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GFAP Antibody (F-7) has 26 citations in a variety of scientific publications.

Primary antibodies like Anti-GFAP Antibody (F-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GFAP Antibody (F-7) Specifications

Alternate Product Name: ALXDRD

Product Clone Name: F-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-19

Epitope Target: GFAP

Epitope Species: human

Product Reactivity/Detection: GFAP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 26 citations in various scientific publications

Available Conjugates/Forms for GFAP Antibody (F-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred GFAP antibody is GFAP Antibody (2E1): sc-33673.