Gemin7 Antibody (5F1): sc-130668

Gemin7 Antibody (5F1) is a mouse monoclonal IgG1 antibody that detects Gemin7 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Gemin7 is a 131 amino acid protein encoded by the mouse gene Gemin7 and plays a crucial role as a significant component of the large multiprotein human SMN complex, which is essential for the assembly of small nuclear ribonucleoproteins (snRNPs), the primary constituents of the spliceosome. The SMN complex is particularly important in the context of spinal muscular atrophy, a common neurodegenerative disease, as it includes the survival of motor neurons (SMN) protein, which is directly linked to the pathology of this condition. Notably, Gemin7, along with Gemin6, forms a heterodimer that interacts through an interface akin to that of Sm proteins, despite lacking significant sequence similarity. This interaction is vital for the organization of Sm proteins, facilitating the formation of Sm rings on snRNA targets, thereby ensuring the proper assembly and function of the spliceosome. Anti-Gemin7 antibody (5F1) serves as an invaluable tool for researchers studying RNA processing and the molecular mechanisms underlying neurodegenerative diseases, providing insights into the intricate roles of the SMN complex in cellular function.

The preferred Gemin7 antibody is Gemin7 Antibody (H-9): sc-514950.