GDF-5 Antibody (A-10): sc-373744

GDF-5 Antibody (A-10) is a mouse monoclonal IgM antibody that detects GDF-5 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-GDF-5 antibody (A-10) is available as the non-conjugated form. GDF-5, also known as growth/differentiation factor 5, plays a crucial role in bone formation and is predominantly expressed in long bones during fetal development, making GDF-5 essential for proper skeletal development. GDF-5 is a member of the transforming growth factor-beta (TGF-β) superfamily, which is known for involvement in various biological processes, including embryonic development and tissue homeostasis. Notably, GDF-5 has been shown to induce plasminogen activator activation, promoting angiogenesis, which is vital for supplying nutrients and oxygen to developing tissues. Mutations in GDF-5 have been linked to skeletal abnormalities, such as the brachypodism mutation in mice, which affects limb bone length and number. Additionally, GDF-5 shares structural similarities with other growth/differentiation factors, including GDF-6 and GDF-7, highlighting GDF-5′s importance in skeletal and tissue development.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

GDF-5 Antibody (A-10) References:

1. Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.  |  Lee, SJ. 1991. Proc Natl Acad Sci U S A. 88: 4250-4. PMID: 2034669
2. The transforming growth factor-beta family.  |  Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
3. Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.  |  Storm, EE., et al. 1994. Nature. 368: 639-43. PMID: 8145850
4. GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines.  |  McPherron, AC. and Lee, SJ. 1993. J Biol Chem. 268: 3444-9. PMID: 8429021
5. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member.  |  McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826
6. Growth/differentiation factor-5 induces angiogenesis in vivo.  |  Yamashita, H., et al. 1997. Exp Cell Res. 235: 218-26. PMID: 9281371

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GDF-5 Antibody (A-10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-GDF-5 Antibody (A-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GDF-5 Antibody (A-10) Specifications

Alternate Product Name: GDF5

Product Clone Name: A-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 375-408

Epitope Target: GDF-5

Epitope Species: human

Product Reactivity/Detection: precursor and mature GDF-5

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for GDF-5 Antibody (A-10): P: Blocking Peptide

The preferred GDF-5/6/7/16 antibody is GDF-5/6/7/16 Antibody (A-2): sc-374184.