GDF-5/6/7/16 Antibody (A-2): sc-374184
- GDF-5/6/7/16 Antibody (A-2) is a mouse monoclonal IgG2b κ GDF-5/6/7/16 antibody provided at 200 µg/ml
- raised against amino acids 382-501 mapping at the C-terminus of GDF-5 of human origin
- GDF-5/6/7/16 Antibody (A-2) is recommended for detection of precursor and mature GDF-5 , GDF-6, GDF-7 and GDF-16 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GDF-5/6/7/16 Antibody (A-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for GDF-5/6/7/16 Antibody (A-2) for WB applications. These reagents are now offered in bundles with GDF-5/6/7/16 Antibody (A-2) (see ordering information below).
GDF-5/6/7/16 Antibody (A-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects GDF-5/6/7/16 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GDF-5/6/7/16 (A-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. GDF-5/6/7/16 proteins are part of the transforming growth factor-beta (TGF-β) superfamily, which plays crucial roles in embryonic development and adult tissue homeostasis maintenance. GDF-5, also known as cartilage-derived morphogenetic protein-1 (CDMP-1), is predominantly expressed in long bones during fetal development and is essential for bone formation and repair. GDF-5′s ability to induce plasminogen activator activation highlights a role in promoting angiogenesis, vital for supplying nutrients and oxygen to developing tissues. Mutations in GDF-5 have been linked to skeletal abnormalities, such as brachypodism mutation in mice, affecting limb bone length and number. GDF-6 and GDF-7 share structural similarities with GDF-5 and are involved in various developmental processes. Anti-GDF-5/6/7/16 antibody (A-2) availability in multiple formats makes this product a versatile tool for researchers studying these growth factors′ roles in development and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GDF-5/6/7/16 Antibody (A-2) References:
- Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure. | Lee, SJ. 1991. Proc Natl Acad Sci U S A. 88: 4250-4. PMID: 2034669
- The transforming growth factor-beta family. | Massagué, J. 1990. Annu Rev Cell Biol. 6: 597-641. PMID: 2177343
- Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily. | Storm, EE., et al. 1994. Nature. 368: 639-43. PMID: 8145850
- GDF-3 and GDF-9: two new members of the transforming growth factor-beta superfamily containing a novel pattern of cysteines. | McPherron, AC. and Lee, SJ. 1993. J Biol Chem. 268: 3444-9. PMID: 8429021
- Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. | McPherron, AC., et al. 1997. Nature. 387: 83-90. PMID: 9139826
- Growth/differentiation factor-5 induces angiogenesis in vivo. | Yamashita, H., et al. 1997. Exp Cell Res. 235: 218-26. PMID: 9281371
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GDF-5/6/7/16 Antibody (A-2) | sc-374184 | 200 µg/ml | $316.00 | |||
GDF-5/6/7/16 Antibody (A-2): m-IgGκ BP-HRP Bundle | sc-522655 | 200 µg Ab, 40 µg BP | $354.00 | |||
GDF-5/6/7/16 Antibody (A-2): m-IgG2b BP-HRP Bundle | sc-549051 | 200 µg Ab; 10 µg BP | $354.00 | |||
GDF-5/6/7/16 Antibody (A-2) AC | sc-374184 AC | 500 µg/ml, 25% agarose | $416.00 | |||
GDF-5/6/7/16 Antibody (A-2) HRP | sc-374184 HRP | 200 µg/ml | $316.00 | |||
GDF-5/6/7/16 Antibody (A-2) FITC | sc-374184 FITC | 200 µg/ml | $330.00 | |||
GDF-5/6/7/16 Antibody (A-2) PE | sc-374184 PE | 200 µg/ml | $343.00 | |||
GDF-5/6/7/16 Antibody (A-2) Alexa Fluor® 488 | sc-374184 AF488 | 200 µg/ml | $357.00 | |||
GDF-5/6/7/16 Antibody (A-2) Alexa Fluor® 546 | sc-374184 AF546 | 200 µg/ml | $357.00 | |||
GDF-5/6/7/16 Antibody (A-2) Alexa Fluor® 594 | sc-374184 AF594 | 200 µg/ml | $357.00 | |||
GDF-5/6/7/16 Antibody (A-2) Alexa Fluor® 647 | sc-374184 AF647 | 200 µg/ml | $357.00 | |||
GDF-5/6/7/16 Antibody (A-2) Alexa Fluor® 680 | sc-374184 AF680 | 200 µg/ml | $357.00 | |||
GDF-5/6/7/16 Antibody (A-2) Alexa Fluor® 790 | sc-374184 AF790 | 200 µg/ml | $357.00 |