GDF-5 Inhibitors
GDF-5 inhibitors belong to a distinctive class of chemical compounds designed to modulate the activity of Growth Differentiation Factor 5 (GDF-5), a member of the transforming growth factor-beta (TGF-β) superfamily. GDF-5 is a crucial signaling molecule involved in various developmental processes, particularly in the formation and maintenance of skeletal tissues. The inhibitors act by selectively targeting and disrupting the signaling pathways associated with GDF-5, thereby regulating its biological effects. These compounds often exhibit high specificity, interacting with key molecular components involved in the GDF-5-mediated cellular responses.
The chemical structures of GDF-5 inhibitors are diverse, reflecting the intricate nature of the interactions within the GDF-5 signaling cascade. Some inhibitors may function by directly binding to the GDF-5 protein, impeding its interaction with cell surface receptors. Others may interfere with downstream intracellular signaling events, modulating the transduction of the GDF-5 signal into cellular responses. The development and refinement of GDF-5 inhibitors represent a significant advancement in molecular pharmacology, providing researchers with valuable tools to elucidate the intricate mechanisms underlying skeletal development and tissue homeostasis. Understanding the precise mode of action of these inhibitors may pave the way for novel insights into the broader TGF-β superfamily signaling and contribute to the development of innovative strategies for modulating cellular processes associated with GDF-5 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
Inhibitor of the TGF-β type I receptor ALK5, which may influence GDF-5 related signaling by altering TGF-β pathway activity. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
A selective ALK2 and ALK3 inhibitor, which may affect BMP signaling pathways that GDF-5 is a part of. | ||||||
DMH-1 | 1206711-16-1 | sc-361171 sc-361171B sc-361171A sc-361171C | 10 mg 25 mg 50 mg 100 mg | $213.00 $318.00 $632.00 $1047.00 | 2 | |
Specific inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3, which are closely related to GDF-5 signaling. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Inhibits BMP signaling and is an inhibitor of ALK2, ALK3, and ALK6, which could alter GDF-5 activity indirectly. | ||||||
LDN-214117 | 1627503-67-6 | sc-507451 | 5 mg | $165.00 | ||
Another BMP receptor kinase inhibitor, designed to be more selective than LDN-193189, potentially affecting GDF-5 function. | ||||||
K02288 | 1431985-92-0 | sc-488981 | 5 mg | $330.00 | ||
A selective inhibitor of ALK2, ALK3, and ALK6, which are involved in BMP signaling pathways that may intersect with GDF-5. | ||||||
LDN 193719 | 1062368-49-3 | sc-489383 | 10 mg | $189.00 | ||
Selective ALK1 and ALK2 inhibitor, which could modulate BMP signaling and consequently the activity of GDF-5. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
Inhibitor of TGF-β type I receptor ALK5, which might modulate GDF-5 signaling through the TGF-β pathway. | ||||||
EW-7197 | 1352608-82-2 | sc-507465 | 5 mg | $345.00 | ||
Another ALK5 inhibitor that targets TGF-β signaling, which can be relevant for GDF-5 functioning. | ||||||
(±)-Hesperetin | 520-33-2 | sc-202647 | 1 g | $47.00 | 4 | |
Flavonoid compound that has been reported to affect TGF-β signaling, potentially influencing GDF-5 activity. | ||||||