GDF-11 Antibody (X-19): sc-81952

GDF-11 Antibody (X-19) is a mouse monoclonal IgG2a kappa light chain antibody that detects GDF-11 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GDF-11 antibody (X-19) is offered in a non-conjugated form, allowing for versatile use in various experimental setups. GDF-11, a crucial member of the Transforming Growth Factor Beta (TGF-β) superfamily, plays a significant role in regulating anterior/posterior patterning of the axial skeleton and organogenesis by modulating the expression of genes such as Gdnf. Notably, GDF-11 is involved in the phosphorylation of Smad2, a key step in TGF-β signaling pathways, which are essential for proper cellular communication and developmental processes. Additionally, GDF-11 mediates Nodal signaling during left-right patterning and is critical for the development of head structures. GDF-11′s inhibitory effect on the generation of new neurons from progenitor cells in the olfactory epithelium highlights GDF-11′s importance in neurogenesis and the maintenance of neural stem cell populations. GDF-11′s ability to influence such diverse biological processes underscores GDF-11′s significance in developmental biology and potential implications in regenerative medicine.

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GDF-11 Antibody (X-19) References:

1. Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11.  |  McPherron, AC., et al. 1999. Nat Genet. 22: 260-4. PMID: 10391213
2. Axis development: the mouse becomes a dachshund.  |  Gad, JM. and Tam, PP. 1999. Curr Biol. 9: R783-6. PMID: 10531023
3. Gdf11 is a negative regulator of chondrogenesis and myogenesis in the developing chick limb.  |  Gamer, LW., et al. 2001. Dev Biol. 229: 407-20. PMID: 11203700
4. Assigning the positional identity of spinal motor neurons: rostrocaudal patterning of Hox-c expression by FGFs, Gdf11, and retinoids.  |  Liu, JP., et al. 2001. Neuron. 32: 997-1012. PMID: 11754833
5. Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning.  |  Oh, SP., et al. 2002. Genes Dev. 16: 2749-54. PMID: 12414726
6. Autoregulation of neurogenesis by GDF11.  |  Wu, HH., et al. 2003. Neuron. 37: 197-207. PMID: 12546816
7. Regulation of metanephric kidney development by growth/differentiation factor 11.  |  Esquela, AF. and Lee, SJ. 2003. Dev Biol. 257: 356-70. PMID: 12729564
8. Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle.  |  Sinha, M., et al. 2014. Science. 344: 649-52. PMID: 24797481
9. Systemic GDF11 attenuates depression-like phenotype in aged mice via stimulation of neuronal autophagy.  |  Moigneu, C., et al. 2023. Nat Aging. 3: 213-228. PMID: 37118117
10. GDF-11 as a Potential Cardiac Pro-Angiogenic Factor.  |  Kato, T. and Lee, RT. 2023. JACC Basic Transl Sci. 8: 636-637. PMID: 37426538
11. Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans.  |  Kraler, S., et al. 2023. Cardiovasc Res. 119: 2729-2742. PMID: 37742057
12. GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21.  |  Wang, DX., et al. 2023. Nat Commun. 14: 7476. PMID: 37978295

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GDF-11 Antibody (X-19) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-GDF-11 Antibody (X-19) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GDF-11 Antibody (X-19) Specifications

Alternate Product Name: GDF-11

Product Clone Name: X-19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 310-408

Epitope Target: GDF-11

Epitope Species: human

Product Reactivity/Detection: GDF-11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for GDF-11 Antibody (X-19): N/A