GCM2 Antibody (C-5): sc-390603
- GCM2 Antibody (C-5) is a mouse monoclonal IgG1 κ GCM2 antibody provided at 200 µg/ml
- raised against amino acids 183-410 mapping within an internal region of GCM2 of human origin
- GCM2 Antibody (C-5) is recommended for detection of GCM2 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-GCM2 Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-390603 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for GCM2 Antibody (C-5). This work is in progress.
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GCM2 Antibody (C-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects GCM2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). GCM2 (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The glial cells missing homolog 2 (GCM2), also known as chorion-specific transcription factor GCMb, is a crucial 506 amino acid nuclear protein that plays a vital role in regulating parathyroid development. GCM2 is essential for mediating calcium effects on parathyroid hormone expression and secretion in parathyroid cells, which maintains calcium homeostasis in the body. GCM2 contains a single N-terminal GCM domain that exhibits DNA binding activity, allowing effective gene expression regulation. Mutations in GCM2 are linked to hypoparathyroidism, an autosomal recessive disorder characterized by low calcium levels and elevated phosphate levels, highlighting GCM2′s significance in endocrine function and metabolic balance.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
GCM2 Antibody (C-5) References:
- GCMB gene, a master regulator of parathyroid gland development, expression, and regulation in hyperparathyroidism. | Kebebew, E., et al. 2004. Surgery. 136: 1261-6. PMID: 15657585
- GCMB mutation in familial isolated hypoparathyroidism with residual secretion of parathyroid hormone. | Thomée, C., et al. 2005. J Clin Endocrinol Metab. 90: 2487-92. PMID: 15728199
- Identification of a novel mutation disrupting the DNA binding activity of GCM2 in autosomal recessive familial isolated hypoparathyroidism. | Baumber, L., et al. 2005. J Med Genet. 42: 443-8. PMID: 15863676
- Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. | Liu, Z., et al. 2007. Dev Biol. 305: 333-46. PMID: 17382312
- Novel gcm-dependent lineages in the postembryonic nervous system of Drosophila melanogaster. | Soustelle, L. and Giangrande, A. 2007. Dev Dyn. 236: 2101-8. PMID: 17654713
- Analysis of the GCM2 gene in isolated hypoparathyroidism: a molecular and biochemical study. | Maret, A., et al. 2008. J Clin Endocrinol Metab. 93: 1426-32. PMID: 18182452
- Dominant-negative GCMB mutations cause an autosomal dominant form of hypoparathyroidism. | Mannstadt, M., et al. 2008. J Clin Endocrinol Metab. 93: 3568-76. PMID: 18583467
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
GCM2 Antibody (C-5) | sc-390603 | 200 µg/ml | $322.00 | |||
GCM2 Antibody (C-5) X | sc-390603 X | 200 µg/0.1 ml | $322.00 | |||
GCM2 Antibody (C-5) AC | sc-390603 AC | 500 µg/ml, 25% agarose | $424.00 | |||
GCM2 Antibody (C-5) HRP | sc-390603 HRP | 200 µg/ml | $322.00 | |||
GCM2 Antibody (C-5) FITC | sc-390603 FITC | 200 µg/ml | $336.00 | |||
GCM2 Antibody (C-5) PE | sc-390603 PE | 200 µg/ml | $349.00 | |||
GCM2 Antibody (C-5) Alexa Fluor® 488 | sc-390603 AF488 | 200 µg/ml | $364.00 | |||
GCM2 Antibody (C-5) Alexa Fluor® 546 | sc-390603 AF546 | 200 µg/ml | $364.00 | |||
GCM2 Antibody (C-5) Alexa Fluor® 594 | sc-390603 AF594 | 200 µg/ml | $364.00 | |||
GCM2 Antibody (C-5) Alexa Fluor® 647 | sc-390603 AF647 | 200 µg/ml | $364.00 | |||
GCM2 Antibody (C-5) Alexa Fluor® 680 | sc-390603 AF680 | 200 µg/ml | $364.00 | |||
GCM2 Antibody (C-5) Alexa Fluor® 790 | sc-390603 AF790 | 200 µg/ml | $364.00 |